HCFC1 and MED25

Number of citations of the paper that reports this interaction (PMID 14983011)
49

Data Source:
HPRD (in vivo, in vitro)

		HCFC1	MED25
Gene Name		host cell factor C1	mediator complex subunit 25
Image
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Mitochondrion Membrane Neuronal Cell Body Set1C/COMPASS Complex SAGA-type Complex MLL5-L Complex MLL1 Complex	Nucleoplasm
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Identical Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)	Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Cell Cycle Positive Regulation Of Gene Expression Release From Viral Latency Regulation Of Protein Complex Assembly Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		Chromatin modifying enzymes Organelle biogenesis and maintenance Chromatin organization Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Mitochondrial biogenesis	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		31 interactors: ASF1B CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIN3A SP1 TAF9 THAP11 THAP7 YY1 ZBTB17	16 interactors: CDK8 CREBBP CTDP1 ESR1 HCFC1 MED1 MED15 MED4 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA
Entrez ID		3054	81857
HPRD ID		02061	14380
Ensembl ID		ENSG00000172534	ENSG00000104973
Uniprot IDs		P51610	Q71SY5
PDB IDs		4GO6	2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Cellular Process Rhythmic Process Negative Regulation Of Cellular Metabolic Process Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Metabolic Process Cellular Response To Stress Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Initiation Response To Oxidative Stress Cellular Response To Organic Substance Circadian Rhythm Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Regulation Of Cell Proliferation	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Cellular Response To Lipid Steroid Hormone Mediated Signaling Pathway Regulation Of Metabolic Process Response To Steroid Hormone Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription From RNA Polymerase II Promoter Steroid Metabolic Process Gland Development Response To Lipid Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Response To Hormone Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		capd3 capg2 condensin conjunction demethylase demethylases dismissal e2f1 ever expanding h3k27me2 h3k4me2 h3k9me1 h4k20me1 intimate jmjc jumonji ncapd3 ncapg2 phd phf8 prophase recognizing removing seq set1a setd1a smc	allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Difference) ?		capd3 capg2 condensin conjunction demethylase demethylases dismissal e2f1 ever expanding h3k27me2 h3k4me2 h3k9me1 h4k20me1 intimate jmjc jumonji ncapd3 ncapg2 phd phf8 prophase recognizing removing seq set1a setd1a smc	allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Intersection) ?