CLP1 and CEP164

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLP1	CEP164
Description		cleavage factor polyribonucleotide kinase subunit 1	centrosomal protein 164
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GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Ciliary Transition Fiber
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity	Protein Binding
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing MRNA Processing TRNA Processing Cerebellar Cortex Development MRNA 3'-end Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage	DNA Repair DNA Damage Response Cell Projection Organization Cell Division Cilium Assembly
Pathways		tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)	Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 30578418) Diffusing capacity of carbon monoxide ( 30694715) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Pulse pressure ( 27841878 28135244 30578418)
Interacting Genes		16 interacting genes: APP CEP164 CPSF3 CREB3 DAGLB FGF16 FTO HCFC1 MEOX2 MESD NUDT21 PCMT1 PRR3 PSMB5 SNF8 YJU2B	6 interacting genes: ATR ATRIP CLP1 MAPK14 UBC XPA
Entrez ID		10978	22897
HPRD ID		16382	10854
Ensembl ID		ENSG00000172409	ENSG00000110274
Uniprot IDs		Q92989	Q9UPV0
PDB IDs		8HMY 8HMZ	7NWJ 7O06 7O0S 7O3B
Enriched GO Terms of Interacting Partners?		Release From Viral Latency Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Cleavage And Polyadenylation Specificity Factor Complex Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Toll Signaling Pathway Chromatin Binding Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity MRNA 3'-end Processing Positive Regulation Of Pro-B Cell Differentiation RNA Repair TRNA Demethylase Activity	ATR-ATRIP Complex Cellular Response To UV Cellular Response To Light Stimulus DNA Damage Checkpoint Signaling Response To UV Signal Transduction In Response To DNA Damage Cellular Response To Radiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition DNA Damage Response Negative Regulation Of Cell Cycle Process Response To Light Stimulus Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Nucleic Acid Metabolic Process Nucleotide-excision Repair, DNA Damage Recognition Response To Radiation Regulation Of Cell Cycle Phase Transition Establishment Of Protein-containing Complex Localization To Telomere Nucleoplasm Establishment Of RNA Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Nucleotide-excision Repair Involved In Interstrand Cross-link Repair ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity DNA Repair Histone H2AXS139 Kinase Activity Regulation Of Synaptic Membrane Adhesion Nucleotide-excision Repair Factor 1 Complex Global Gene Silencing By MRNA Cleavage Kinase Activity Response To Ionizing Radiation Regulation Of Double-strand Break Repair TRNA-intron Endonuclease Complex ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Cellular Response To Stress DNA Metabolic Process Regulation Of Cell Cycle Process NFAT Protein Binding MRNA Cleavage Factor Complex Response To Mechanical Stimulus MutSalpha Complex Binding Macromolecule Metabolic Process MutLalpha Complex Binding Mitogen-activated Protein Kinase P38 Binding Stress-induced Premature Senescence Cerebellar Cortex Development Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
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