HCFC1 and PSIP1

Number of citations of the paper that reports this interaction (PubMedID 9822615)
65

Data Source:
HPRD (in vitro)

		HCFC1	PSIP1
Description		host cell factor C1	PC4 and SRSF1 interacting protein 1
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Membrane Protein-containing Complex Histone Methyltransferase Complex Neuronal Cell Body NSL Complex MLL1/2 Complex Set1C/COMPASS Complex MLL1 Complex	Euchromatin Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Periphery
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Protein-macromolecule Adaptor Activity Chromatin DNA Binding Identical Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Release From Viral Latency Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization	MRNA 5'-splice Site Recognition Chromatin Remodeling Response To Oxidative Stress Response To Heat Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases Formation of WDR5-containing histone-modifying complexes	Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)
Interacting Genes		34 interacting genes: ASF1B CEBPA CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIAH1 SIN3A SP1 SUMO2 TAF9 THAP11 THAP7 ZBTB17	18 interacting genes: CASP3 CASP7 CDC42 CEBPA CSNK2A1 HCFC1 HMGA1 HMGA2 KMT2A MAPK6 MTDH OGT SP1 SRSF1 SUB1 SUMO1 UBC USP7
Entrez ID		3054	11168
HPRD ID		02061	04688
Ensembl ID		ENSG00000172534	ENSG00000164985
Uniprot IDs		A6NEM2 P51610	O75475
PDB IDs		4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5	1Z9E 2B4J 2M16 2MSR 2MTN 2N3A 3F9K 3HPG 3HPH 3U88 3ZEH 4FU6 5N88 5OYM 5YI9 6EMO 6EMP 6EMQ 6EMR 6S01 6TRJ 6TVM 6ZV0 7OUF 7OUG 7OUH 7PEL 7Z1Z 8CBN 8CBQ 8PC5 8PC6 8PEO 8PEP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Chromatin Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Transcription Regulator Complex Integrated Stress Response Signaling Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Circadian Regulation Of Gene Expression	Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Metabolic Process Rhythmic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Execution Phase Of Apoptosis Negative Regulation Of Biosynthetic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of RNA Metabolic Process Cellular Response To Staurosporine Senescence-associated Heterochromatin Focus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Pyroptotic Inflammatory Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis 5'-deoxyribose-5-phosphate Lyase Activity Oncogene-induced Cell Senescence Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Protein Stability Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
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