MALT1 and UBE2N

Number of citations of the paper that reports this interaction (PubMedID 14695475)
0

Data Source:
BioGRID (pull down)

		MALT1	UBE2N
Description		MALT1 paracaspase	ubiquitin conjugating enzyme E2 N
Image
GO Annotations	Cellular Component	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Activity Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Hydrolase Activity Kinase Activator Activity Small Molecule Binding Identical Protein Binding Endopeptidase Activator Activity	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	B-1 B Cell Differentiation Immune System Process Positive Regulation Of Immune Effector Process Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Proteolysis Defense Response Response To Fungus Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Nuclear Export Positive Regulation Of Multicellular Organismal Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Positive Regulation Of T-helper 17 Cell Differentiation	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Regulation Of DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Antiviral Innate Immune Response Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway	ISG15 antiviral mechanism NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 21833088 31604244)	Height ( 18391951) Mean reticulocyte volume ( 32888494)
Interacting Genes		15 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2	124 interacting genes: AMFR ARIH1 ARIH2 ARK2C AURKA BARD1 BCL10 BFAR BIRC2 BIRC3 BIRC8 BRCA1 CADPS2 CBL CCNB1 CHFR CHUK CNOT4 DTL DTX1 DTX3 DZIP3 F12 H2AC4 HERC2 HSP90AA1 LRSAM1 MALT1 MARCHF5 MARCHF7 MDM2 MIB1 MIB2 MID1 MKRN3 MUL1 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PEDS1 PEDS1-UBE2V1 PELI1 PELI3 PJA2 PRKN PTTG1 RBCK1 RBX1 RC3H1 RC3H2 RFFL RFWD3 RIPK1 RNF103 RNF11 RNF111 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF135 RNF152 RNF167 RNF168 RNF181 RNF182 RNF38 RNF4 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SIAH2 SLC2A4 STUB1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TREX2 TRIM13 TRIM14 TRIM15 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM34 TRIM39 TRIM5 TRIM50 TRIM54 TRIM63 TRIM65 TRIM69 TRIM7 TRIM72 UBA1 UBB UBE2V1 UBE2V2 UBE3A UBE3B UHRF1 XIAP ZNRF2 ZNRF3 ZNRF4
Entrez ID		10892	7334
HPRD ID		06892	04725
Ensembl ID		ENSG00000172175	ENSG00000177889
Uniprot IDs		A8K5S1 Q9UDY8	P61088 V9HW41
PDB IDs		2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9 7A41 7AK0 7AK1 7PAV 7PAW 8CZO 8J5I 8V4X	1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA 5H7S 5VNZ 5VO0 5YWR 6D6I 6JKY 6KFP 6KG6 6KL4 6LP2 6P5B 6S53 6ULH 6UMP 6UMS 7BBD 7BBF 7BXG 9BIV
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Regulation Of Protein Ubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Nucleoplasm Positive Regulation Of Post-translational Protein Modification Ubiquitin Protein Ligase Binding Protein Modification Process Positive Regulation Of Protein Modification Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Modification Process Histone H3R2 Methyltransferase Activity UBC13-MMS2 Complex Histone Arginine N-methyltransferase Activity Ubiquitin Ligase Complex Positive Regulation Of DNA-binding Transcription Factor Activity Histone Methyltransferase Activity Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Cellular Response To Stress T-helper 1 Type Immune Response CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Protein-macromolecule Adaptor Activity Protein-containing Complex CD40 Receptor Complex Protein Kinase B Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Regulation Of DNA Repair Positive Regulation Of JUN Kinase Activity	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Polyubiquitination Zinc Ion Binding Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Macromolecule Catabolic Process Metal Ion Binding Protein K63-linked Ubiquitination Protein Autoubiquitination Proteolysis Catabolic Process Protein K48-linked Ubiquitination Response To Stress Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Signaling Regulation Of Cell Communication Protein Monoubiquitination Immune System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Defense Response To Symbiont Cytoplasm Defense Response To Other Organism Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Metabolic Process
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