MALT1 and FEM1C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MALT1	FEM1C
Description		MALT1 paracaspase	fem-1 homolog C
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GO Annotations	Cellular Component	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protease Binding Endopeptidase Activity Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Hydrolase Activity Kinase Activator Activity Small Molecule Binding Identical Protein Binding Endopeptidase Activator Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	B-1 B Cell Differentiation Immune System Process Positive Regulation Of Immune Effector Process Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Proteolysis Defense Response Response To Fungus Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Nuclear Export Positive Regulation Of Multicellular Organismal Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Positive Regulation Of T-helper 17 Cell Differentiation	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway	Neddylation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 21833088 31604244)	Conotruncal heart defects (inherited effects) ( 28468790) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		15 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2	10 interacting genes: BCL2L11 CDK5R1 CEP63 LZTS2 MALT1 MCM8 OR51B2 PNMA1 RPGRIP1 SIL1
Entrez ID		10892	56929
HPRD ID		06892	16384
Ensembl ID		ENSG00000172175	ENSG00000145780
Uniprot IDs		A8K5S1 Q9UDY8	Q96JP0
PDB IDs		2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9 7A41 7AK0 7AK1 7PAV 7PAW 8CZO 8J5I 8V4X	6LBG 6LBN 6LDP 6LE6 6LEN 6LEY 6LF0 6XKC 7JYA 8PQL 8Q7R
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Regulation Of Protein Ubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Nucleoplasm Positive Regulation Of Post-translational Protein Modification Ubiquitin Protein Ligase Binding Protein Modification Process Positive Regulation Of Protein Modification Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Modification Process Histone H3R2 Methyltransferase Activity UBC13-MMS2 Complex Histone Arginine N-methyltransferase Activity Ubiquitin Ligase Complex Positive Regulation Of DNA-binding Transcription Factor Activity Histone Methyltransferase Activity Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Cellular Response To Stress T-helper 1 Type Immune Response CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Protein-macromolecule Adaptor Activity Protein-containing Complex CD40 Receptor Complex Protein Kinase B Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Regulation Of DNA Repair Positive Regulation Of JUN Kinase Activity
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