MALT1 and UBE2V2

Number of citations of the paper that reports this interaction (PMID 14695475)
121

Data Source:
BioGRID (pull down)

		MALT1	UBE2V2
Gene Name		MALT1 paracaspase	ubiquitin-conjugating enzyme E2 variant 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane CBM Complex Protein Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm UBC13-MMS2 Complex Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Peptidase Activity Kinase Activator Activity Protein Self-association	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	B-1 B Cell Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of T Cell Cytokine Production Proteolysis Defense Response Activation Of NF-kappaB-inducing Kinase Activity Response To Fungus Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Nuclear Export Protein Oligomerization	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Cell Proliferation Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of Synapse Assembly Protein K63-linked Ubiquitination
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		12 interactors: BCL10 CARM1 IKBKG KDM1A PRMT6 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBE2N UBE2V2	22 interactors: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 OTUB1 RNF144A RNF2 RNF8 SHPRH SIAH1 SUV39H2 TRAF2 TRIM5 UBC UBE2N XIAP ZNRF1
Entrez ID		10892	7336
HPRD ID		06892	04300
Ensembl ID		ENSG00000172175
Uniprot IDs		A8K5S1 Q9UDY8	A0M8W4 G3V113 Q15819
PDB IDs		2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1R	1J74 1J7D 1ZGU 3VON 4EPO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Protein K63-linked Ubiquitination NIK/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Stress Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Innate Immune Response Response To Stress Regulation Of Nitrogen Compound Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Innate Immune Response Negative Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Cell Death Activation Of NF-kappaB-inducing Kinase Activity T Cell Receptor Signaling Pathway Histone H3-R2 Methylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Regulation Of Cellular Protein Metabolic Process Histone Modification Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Metabolic Process Innate Immune Response Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Intracellular Receptor Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of DNA Repair Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Histone Ubiquitination Regulation Of Histone Ubiquitination Positive Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus Cellular Response To DNA Damage Stimulus Antigen Receptor-mediated Signaling Pathway Cellular Metabolic Process Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Immune System Process DNA Repair Protein Catabolic Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Chromatin Organization Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		api2 bcl2 cd10 cd23 cd5 demonstration destroying diagnose discrete excludes follicular glandular infiltrate invading lamina lymphatic lymphocytic lymphoepithelial lymphoma lymphomas mantle marginal mucosae propria q21 rearrangement stomach suspicious	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a
Tagcloud (Difference) ?		api2 bcl2 cd10 cd23 cd5 demonstration destroying diagnose discrete excludes follicular glandular infiltrate invading lamina lymphatic lymphocytic lymphoepithelial lymphoma lymphomas mantle marginal mucosae propria q21 rearrangement stomach suspicious	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a
Tagcloud (Intersection) ?