MALT1 and RELB

Number of citations of the paper that reports this interaction (PMID 21873235)
18

Data Source:
BioGRID (enzymatic study)

		MALT1	RELB
Gene Name		MALT1 paracaspase	v-rel avian reticuloendotheliosis viral oncogene homolog B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane CBM Complex Protein Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol I-kappaB/NF-kappaB Complex
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Peptidase Activity Kinase Activator Activity Protein Self-association	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding
	Biological Process	B-1 B Cell Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of T Cell Cytokine Production Proteolysis Defense Response Activation Of NF-kappaB-inducing Kinase Activity Response To Fungus Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Nuclear Export Protein Oligomerization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Antigen Processing And Presentation Circadian Regulation Of Gene Expression Response To Cytokine NIK/NF-kappaB Signaling Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Osmotic Stress
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		12 interactors: BCL10 CARM1 IKBKG KDM1A PRMT6 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBE2N UBE2V2	25 interactors: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11
Entrez ID		10892	5971
HPRD ID		06892	06886
Ensembl ID		ENSG00000172175	ENSG00000104856
Uniprot IDs		A8K5S1 Q9UDY8	D6R992 Q01201
PDB IDs		2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Protein K63-linked Ubiquitination NIK/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Stress Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Innate Immune Response Response To Stress Regulation Of Nitrogen Compound Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Innate Immune Response Negative Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Cell Death Activation Of NF-kappaB-inducing Kinase Activity T Cell Receptor Signaling Pathway Histone H3-R2 Methylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Regulation Of Cellular Protein Metabolic Process Histone Modification Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Metabolic Process Innate Immune Response Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Intracellular Receptor Signaling Pathway	Nucleosome Disassembly Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Organization Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated ATP-dependent Chromatin Remodeling Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Activation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Negative Regulation Of Gene Expression Chromosome Organization Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Protein Complex Disassembly Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Metabolic Process Toll-like Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Nucleosome Organization Response To Inorganic Substance Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Hydrogen Peroxide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Chromatin Assembly Or Disassembly Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		api2 bcl2 cd10 cd23 cd5 demonstration destroying diagnose discrete excludes follicular glandular infiltrate invading lamina lymphatic lymphocytic lymphoepithelial lymphoma lymphomas mantle marginal mucosae propria q21 rearrangement stomach suspicious	balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify rela s32 s36 serines
Tagcloud (Difference) ?		api2 bcl2 cd10 cd23 cd5 demonstration destroying diagnose discrete excludes follicular glandular infiltrate invading lamina lymphatic lymphocytic lymphoepithelial lymphoma lymphomas mantle marginal mucosae propria q21 rearrangement stomach suspicious	balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify rela s32 s36 serines
Tagcloud (Intersection) ?