FTCD and SNRNP70

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		FTCD	SNRNP70
Description		formimidoyltransferase cyclodeaminase	small nuclear ribonucleoprotein U1 subunit 70
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck Lysosomal Lumen U2-type Prespliceosome Ribonucleoprotein Complex
	Molecular Function	Catalytic Activity Protein Binding Folic Acid Binding Microtubule Binding Transferase Activity Lyase Activity Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding U1 SnRNA Binding U1 SnRNP Binding
	Biological Process	L-histidine Metabolic Process Folic Acid-containing Compound Metabolic Process Cytoskeleton Organization L-histidine Catabolic Process To Glutamate And Formamide L-histidine Catabolic Process To Glutamate And Formate	MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chaperone-mediated Autophagy
Pathways		Histidine catabolism	mRNA Splicing - Major Pathway
Drugs		Tetrahydrofolic acid Glutamic acid (6R)-Folinic acid
Diseases
GWAS		Blood protein levels ( 30072576) Mastocytosis ( 32752121) Refractive error ( 32231278)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653) Venous thromboembolism ( 33592630)
Interacting Genes		23 interacting genes: BEX3 BIRC2 CCDC183 DGCR6 DNM1 DST EIF4A1 EIF4A2 GAD2 HGS HSPA1A HSPA1B HSPA2 IDS KASH5 MED4 NAA25 PALS1 RDX SNRNP70 SPTBN1 USP34 ZMYM5	67 interacting genes: ADARB1 APP ARSF BACE2 CASP3 CBS CDC42 CDKL3 CEBPA CEP63 CFAP298 CHERP CRP CTDP1 DDX17 DYRK1A FTCD GATD3 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 HUNK IL32 IL7R ITSN1 LRP1 MYC NUDT21 OGT PDE9A PIGP PRKD2 PRMT5 PRPF40A PRPF6 PSMG1 RASGRF1 RBM11 RELA RIPPLY3 RNF11 RSPH1 RUNX1 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SPATC1L SRPK1 SRRM4 SRSF1 SRSF10 SRSF2 SUMO3 TIAM1 USP25 USP7 WBP4 ZRANB2
Entrez ID		10841	6625
HPRD ID		08430	01617
Ensembl ID		ENSG00000160282	ENSG00000104852
Uniprot IDs		O95954	P08621 Q9UFS1
PDB IDs			2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9 7B0Y 7VPX 8R08
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Inclusion Body Assembly Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Inclusion Body Assembly Response To Heat Protein Refolding ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Cellular Component Organization Cellular Response To Heat Positive Regulation Of Microtubule Nucleation Response To Temperature Stimulus Protein Folding Chaperone Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process RNA Binding ATP Hydrolysis Activity Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Negative Regulation Of Post-translational Protein Modification Inclusion Body Regulation Of Microtubule Nucleation Regulation Of Post-translational Protein Modification Regulation Of Mitotic Spindle Assembly Protein-containing Complex Unfolded Protein Binding Blood Microparticle Histone Deacetylase Binding Protein Localization To Membrane Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Clathrin Coat Assembly Involved In Endocytosis Cytoplasmic Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Positive Regulation Of Male Mating Behavior Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Erythrocyte Differentiation Aggresome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	SMAD Protein Complex MRNA Processing Heteromeric SMAD Protein Complex RNA Metabolic Process RNA Processing RNA Splicing Nucleoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process I-SMAD Binding Regulation Of MRNA Splicing, Via Spliceosome SMAD Protein Signal Transduction RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Growth Factor Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Positive Regulation Of Developmental Process Identical Protein Binding Embryonic Pattern Specification Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cardiac Conduction System Development Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Transcription Spliceosomal SnRNP Assembly Nuclear Speck Positive Regulation Of Cell Differentiation Spliceosomal Complex Assembly Protein-containing Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression DEAD/H-box RNA Helicase Binding RNA Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process
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