FTCD and NAA25

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		FTCD	NAA25
Description		formimidoyltransferase cyclodeaminase	N-alpha-acetyltransferase 25, NatB auxiliary subunit
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome	Cytoplasm Golgi Apparatus Cytosol NatB Complex
	Molecular Function	Catalytic Activity Protein Binding Folic Acid Binding Microtubule Binding Transferase Activity Lyase Activity Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity	Protein Binding Acetyltransferase Activator Activity
	Biological Process	L-histidine Metabolic Process Folic Acid-containing Compound Metabolic Process Cytoskeleton Organization L-histidine Catabolic Process To Glutamate And Formamide L-histidine Catabolic Process To Glutamate And Formate	Cytoskeleton Organization
Pathways		Histidine catabolism
Drugs		Tetrahydrofolic acid Glutamic acid (6R)-Folinic acid
Diseases			Type I diabetes mellitus
GWAS		Blood protein levels ( 30072576) Mastocytosis ( 32752121) Refractive error ( 32231278)	Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Chronotype ( 30696823) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Epilepsy ( 33913524) Estimated glomerular filtration rate ( 31152163) Fish consumption ( 32895509) Glycated hemoglobin levels ( 34059833) Gout (combined type) ( 32238385) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 30226566) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to alcohol consumption (flushing response) ( 29460428) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Urate levels ( 31578528) Weight ( 34054925)
Interacting Genes		23 interacting genes: BEX3 BIRC2 CCDC183 DGCR6 DNM1 DST EIF4A1 EIF4A2 GAD2 HGS HSPA1A HSPA1B HSPA2 IDS KASH5 MED4 NAA25 PALS1 RDX SNRNP70 SPTBN1 USP34 ZMYM5	2 interacting genes: APP FTCD
Entrez ID		10841	80018
HPRD ID		08430	08578
Ensembl ID		ENSG00000160282	ENSG00000111300
Uniprot IDs		O95954	Q14CX7
PDB IDs			6VP9 7STX 8G0L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Inclusion Body Assembly Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Inclusion Body Assembly Response To Heat Protein Refolding ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Cellular Component Organization Cellular Response To Heat Positive Regulation Of Microtubule Nucleation Response To Temperature Stimulus Protein Folding Chaperone Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process RNA Binding ATP Hydrolysis Activity Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Negative Regulation Of Post-translational Protein Modification Inclusion Body Regulation Of Microtubule Nucleation Regulation Of Post-translational Protein Modification Regulation Of Mitotic Spindle Assembly Protein-containing Complex Unfolded Protein Binding Blood Microparticle Histone Deacetylase Binding Protein Localization To Membrane Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Clathrin Coat Assembly Involved In Endocytosis Cytoplasmic Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Positive Regulation Of Male Mating Behavior Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Erythrocyte Differentiation Aggresome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Microtubule-based Transport Transport Along Microtubule Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Target-directed MiRNA Degradation Elongin Complex L-histidine Metabolic Process L-histidine Catabolic Process L-histidine Catabolic Process To Glutamate And Formate Centriole Glutamate Formimidoyltransferase Activity L-histidine Catabolic Process To Glutamate And Formamide Formimidoyltetrahydrofolate Cyclodeaminase Activity Formate Metabolic Process Intraciliary Transport Involved In Cilium Assembly Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Smooth Endoplasmic Reticulum Membrane Peptidase Activator Activity
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