FTCD and USP34

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		FTCD	USP34
Description		formimidoyltransferase cyclodeaminase	ubiquitin specific peptidase 34
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome	Nucleus Cytosol
	Molecular Function	Catalytic Activity Protein Binding Folic Acid Binding Microtubule Binding Transferase Activity Lyase Activity Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	L-histidine Metabolic Process Folic Acid-containing Compound Metabolic Process Cytoskeleton Organization L-histidine Catabolic Process To Glutamate And Formamide L-histidine Catabolic Process To Glutamate And Formate	Proteolysis Regulation Of Signal Transduction Wnt Signaling Pathway Protein Deubiquitination Regulation Of Protein Stability Post-translational Protein Modification Protein K48-linked Deubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Histidine catabolism	TCF dependent signaling in response to WNT Ub-specific processing proteases
Drugs		Tetrahydrofolic acid Glutamic acid (6R)-Folinic acid
Diseases
GWAS		Blood protein levels ( 30072576) Mastocytosis ( 32752121) Refractive error ( 32231278)	Atrial fibrillation ( 30061737) Body fat mass ( 28552196) Chronotype ( 30696823) Crohn's disease ( 22412388) Diastolic blood pressure ( 30224653) Erectile dysfunction ( 30583798) Estimated glomerular filtration rate ( 31152163) Height ( 31562340) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Morning person ( 30696823) Mosquito bite size ( 28199695) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211 29403010) Urate levels ( 31578528)
Interacting Genes		23 interacting genes: BEX3 BIRC2 CCDC183 DGCR6 DNM1 DST EIF4A1 EIF4A2 GAD2 HGS HSPA1A HSPA1B HSPA2 IDS KASH5 MED4 NAA25 PALS1 RDX SNRNP70 SPTBN1 USP34 ZMYM5	5 interacting genes: DYRK1A FTCD MTNR1A MTNR1B UBC
Entrez ID		10841	9736
HPRD ID		08430	11665
Ensembl ID		ENSG00000160282	ENSG00000115464
Uniprot IDs		O95954	Q70CQ2
PDB IDs			7W3R 7W3U
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Inclusion Body Assembly Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Inclusion Body Assembly Response To Heat Protein Refolding ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Cellular Component Organization Cellular Response To Heat Positive Regulation Of Microtubule Nucleation Response To Temperature Stimulus Protein Folding Chaperone Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process RNA Binding ATP Hydrolysis Activity Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Negative Regulation Of Post-translational Protein Modification Inclusion Body Regulation Of Microtubule Nucleation Regulation Of Post-translational Protein Modification Regulation Of Mitotic Spindle Assembly Protein-containing Complex Unfolded Protein Binding Blood Microparticle Histone Deacetylase Binding Protein Localization To Membrane Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Clathrin Coat Assembly Involved In Endocytosis Cytoplasmic Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Positive Regulation Of Male Mating Behavior Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Erythrocyte Differentiation Aggresome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Melatonin Receptor Activity Histone H3T45 Kinase Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Camera-type Eye Development Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Axonemal Basal Plate L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide Regulation Of Embryonic Cell Shape Eye Development Circadian Rhythm Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Sensory Organ Development Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep L-histidine Metabolic Process L-histidine Catabolic Process Formate Metabolic Process Septin Cytoskeleton Organization Tongue Morphogenesis Auditory Receptor Cell Morphogenesis Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Podocyte Cell Migration Smooth Endoplasmic Reticulum Membrane Respiratory System Development Rhythmic Process Regulation Of Heterochromatin Formation Digestive System Development RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Folic Acid Binding Neurofilament Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Amide Catabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Tag Activity Hormone Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Plasma Membrane Regulation Of Transmission Of Nerve Impulse
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