FTCD and HSPA2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		FTCD	HSPA2
Description		formimidoyltransferase cyclodeaminase	heat shock protein family A (Hsp70) member 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle
	Molecular Function	Catalytic Activity Protein Binding Folic Acid Binding Microtubule Binding Transferase Activity Lyase Activity Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding Glycolipid Binding ATP-dependent Protein Folding Chaperone
	Biological Process	L-histidine Metabolic Process Folic Acid-containing Compound Metabolic Process Cytoskeleton Organization L-histidine Catabolic Process To Glutamate And Formamide L-histidine Catabolic Process To Glutamate And Formate	Protein Folding Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly
Pathways		Histidine catabolism	Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase PKR-mediated signaling
Drugs		Tetrahydrofolic acid Glutamic acid (6R)-Folinic acid	Quercetin
Diseases
GWAS		Blood protein levels ( 30072576) Mastocytosis ( 32752121) Refractive error ( 32231278)	Appendicular lean mass ( 33097823)
Interacting Genes		23 interacting genes: BEX3 BIRC2 CCDC183 DGCR6 DNM1 DST EIF4A1 EIF4A2 GAD2 HGS HSPA1A HSPA1B HSPA2 IDS KASH5 MED4 NAA25 PALS1 RDX SNRNP70 SPTBN1 USP34 ZMYM5	14 interacting genes: APP BAG4 CDK1 CRBN EWSR1 FTCD HSPBP1 MAP3K3 MEOX2 PARP1 RNF144A SAE1 TRIM38 UBE3A
Entrez ID		10841	3306
HPRD ID		08430	07174
Ensembl ID		ENSG00000160282	ENSG00000126803
Uniprot IDs		O95954	P54652
PDB IDs			3I33 4FSV 5FPD 5FPE 5FPM 5FPN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Inclusion Body Assembly Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Inclusion Body Assembly Response To Heat Protein Refolding ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Cellular Component Organization Cellular Response To Heat Positive Regulation Of Microtubule Nucleation Response To Temperature Stimulus Protein Folding Chaperone Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process RNA Binding ATP Hydrolysis Activity Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Negative Regulation Of Post-translational Protein Modification Inclusion Body Regulation Of Microtubule Nucleation Regulation Of Post-translational Protein Modification Regulation Of Mitotic Spindle Assembly Protein-containing Complex Unfolded Protein Binding Blood Microparticle Histone Deacetylase Binding Protein Localization To Membrane Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Clathrin Coat Assembly Involved In Endocytosis Cytoplasmic Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Positive Regulation Of Male Mating Behavior Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Erythrocyte Differentiation Aggresome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Post-translational Protein Modification Protein Modification Process Regulation Of Protein Localization Regulation Of Circadian Rhythm Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Adenyl-nucleotide Exchange Factor Activity Transferase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Response To Copper Ion NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Nerve Growth Factor Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Amyloid-beta NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Pronuclear Fusion Limb Development Sperm Entry Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Golgi Lumen Acidification Negative Regulation Of MRNA Modification Regulation Of Protein Targeting To Mitochondrion Protein Sumoylation Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Modification-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Primary Metabolic Process Response To Amyloid-beta Positive Regulation Of Macromolecule Metabolic Process
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