DGAT1 and GABRA4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DGAT1	GABRA4
Description		diacylglycerol O-acyltransferase 1	gamma-aminobutyric acid type A receptor subunit alpha4
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	2-acylglycerol O-acyltransferase Activity Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding Retinol O-fatty-acyltransferase Activity	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Lipid Storage Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Retinol Metabolic Process Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Fatty Acid Homeostasis	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Central Nervous System Development Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Acyl chain remodeling of DAG and TAG Neutrophil degranulation Triglyceride biosynthesis	GABA receptor activation GABA receptor activation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Clobazam Meprobamate Meprobamate Eszopiclone Alprazolam Secobarbital Metharbital Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Primidone Halazepam Propofol Diazepam Oxazepam Methylphenobarbital Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Dupuytren's disease ( 28886342) Fasting glucose ( 34059833)	Cognitive decline (age-related) ( 28078323) Polycystic ovary syndrome ( 30343302) Type 2 diabetes ( 23937595)
Interacting Genes		3 interacting genes: CCR9 CD1A GABRA4	4 interacting genes: APP DGAT1 PRKCG SNCA
Entrez ID		8694	2557
HPRD ID		05360	08839
Ensembl ID		ENSG00000185000	ENSG00000109158
Uniprot IDs		O75907	P48169 X5D7F5
PDB IDs		6VP0 6VYI 6VZ1 8ESM 8ETM	7QN5 7QN7 7QN9 7QNA 7QNC
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Exogenous Lipid Antigen Binding Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Endogenous Lipid Antigen Binding GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Protein Retention In ER Lumen Lipopeptide Binding GPI Anchor Binding External Side Of Plasma Membrane Benzodiazepine Receptor Activity Gamma-delta T Cell Differentiation Maintenance Of Protein Localization In Endoplasmic Reticulum GABA-A Receptor Activity GABA-A Receptor Complex GABA-gated Chloride Ion Channel Activity Inhibitory Synapse Assembly Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Gamma-delta T Cell Activation Antigen Processing And Presentation Of Endogenous Antigen Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Dendrite Membrane Synaptic Transmission, GABAergic Positive Regulation Of T Cell Mediated Cytotoxicity Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Positive Regulation Of Synaptic Transmission Regulation Of Neuron Apoptotic Process Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Neurotransmitter Uptake Cellular Response To Copper Ion Response To Copper Ion Chemical Synaptic Transmission Amyloid Fibril Formation Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Endocytosis Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Catabolic Process Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Synaptic Membrane Modulation Of Chemical Synaptic Transmission Macrophage Activation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Vesicle-mediated Transport Response To Interleukin-1 Adult Locomotory Behavior Neutral Lipid Metabolic Process Regulation Of Neurotransmitter Secretion Amyloid-beta Complex Cell-cell Signaling Growth Cone Lamellipodium Cell Communication Regulation Of Response To Calcium Ion Amylin Binding Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Signaling Response To Alkaloid Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Perinuclear Region Of Cytoplasm Negative Regulation Of Protein Catabolic Process Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Reactive Oxygen Species Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Calcium Ion Transmembrane Transport
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