FZD3 and GIPC2

Number of citations: 0 (PubMedID 12011974)
Data Source: HPRD (in vivo)

		FZD3	GIPC2
Name		frizzled class receptor 3	GIPC PDZ domain containing family member 2
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Filopodium Tip Neuronal Cell Body Apical Part Of Cell Presynaptic Active Zone Presynaptic Active Zone Membrane Glutamatergic Synapse	Cytoplasm Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Positive Regulation Of Neuroblast Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Response To Xenobiotic Stimulus Wnt Signaling Pathway Neuron Differentiation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Inner Ear Morphogenesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Response To Electrical Stimulus Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Sympathetic Ganglion Development Commissural Neuron Axon Guidance Motor Neuron Migration Negative Regulation Of Execution Phase Of Apoptosis Midbrain Morphogenesis	None
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Asymmetric localization of PCP proteins	None
GWAS		No GWAS studies recorded	Age at first birth ( 34211149 ) Body mass index ( 29273807 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) End-stage kidney disease ( 31178898 ) Hand grip strength ( 29691431 ) Height ( 20881960 25282103 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference ( 25673412 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Platelet distribution width ( 32888494 ) Post bronchodilator FEV1 ( 26634245 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Severe influenza A (H1N1) infection ( 26379185 )
Novel Interactors		2 novel interactors: ADORA2A CLCN3	None recorded
Interacting Genes		3 interacting genes: GIPC1 GIPC2 GIPC3	14 interacting genes: CTRC FZD3 IGSF21 IRF4 LZTS2 PATJ PLEKHA2 PTN SETDB1 SP100 UBE2I UNC119 ZBTB26 ZCCHC7
Entrez ID		7976	54810
HPRD ID		05849	17040
Ensembl ID		ENSG00000104290	ENSG00000137960
Uniprot IDs		Q9NPG1	A0A384P5H2 Q8TF65
PDB IDs		8JHC 8JHI 8Q7O 8QW4	3GGE
GO Terms Enriched among Interactors		Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Transmission, Glutamatergic Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Vesicle Membrane Glutamatergic Synapse Cell-cell Signaling Cell Communication Signaling Synaptic Vesicle Chloride:proton Antiporter Activity Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Synaptic Plasticity Locomotory Behavior G Protein-coupled Adenosine Receptor Activity Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Norepinephrine Secretion Synaptic Transmission, Dopaminergic Prepulse Inhibition Inhibitory Postsynaptic Potential Positive Regulation Of Urine Volume Asymmetric Synapse Positive Regulation Of Glutamate Secretion Axolemma Alpha-actinin Binding Response To Caffeine G Protein-coupled Adenosine Receptor Signaling Pathway Specific Granule Endosomal Lumen Acidification Voltage-gated Chloride Channel Activity Cellular Response To Interleukin-7 Regulation Of Melanin Biosynthetic Process Response To Interleukin-7 Positive Regulation Of Melanin Biosynthetic Process Glutamate Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Circadian Rhythm Regulation Of Urine Volume Astrocyte Activation Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Vascular Permeability Chloride Transmembrane Transporter Activity	None