RAI2 and APPL2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		RAI2	APPL2
Description		retinoic acid induced 2	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Image
GO Annotations	Cellular Component	Nucleus	Ruffle Nucleus Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Bounding Membrane Of Organelle
	Molecular Function	Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Embryo Development Ending In Birth Or Egg Hatching Animal Organ Development	Diet Induced Thermogenesis Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Homeostatic Process Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of D-glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Prostate-specific antigen levels ( 28139693)	Mosquito bite size ( 28199695)
Interacting Genes		13 interacting genes: APP APPL2 ATXN1 CTBP1 CTBP2 DOK5 FHL2 FXR2 SGTB TRIM55 TRIM63 UBQLN1 UBQLN4	31 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 CRYAA DOK3 EPM2AIP1 HUNK KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1
Entrez ID		10742	55198
HPRD ID		02199	06945
Ensembl ID		ENSG00000131831	ENSG00000136044
Uniprot IDs		B2RBE9 B3KPD7 Q9Y5P3	Q8NEU8
PDB IDs		8ARI 8ATI	4H8S 5C5B
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process White Fat Cell Differentiation Viral Genome Replication Regulation Of Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Nucleus Negative Regulation Of Macromolecule Metabolic Process NAD Binding Amyloid-beta Complex Protein Homooligomerization Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Cytoplasm Transcription Corepressor Activity Transcription Coregulator Binding Transcription Corepressor Binding Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Regulation Of Neuronal Synaptic Plasticity Regulation Of Primary Metabolic Process Protein Complex Oligomerization Negative Regulation Of Biosynthetic Process Visual Behavior Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Transcription Repressor Complex Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Atrial Cardiac Muscle Cell Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation TRC Complex Positive Regulation Of Macropinocytosis Nuclear Proteasome Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of ATP Metabolic Process	Telomere Assembly Regulation Of Cellular Component Organization Response To Oxygen Levels Response To Decreased Oxygen Levels Plasma Membrane To Endosome Transport GDP Binding Early Phagosome NuRD Complex Chromosome, Telomeric Region Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Positive Regulation Of Telomere Maintenance Regulation Of DNA Strand Elongation Nuclear Telomere Cap Complex Shelterin Complex Telomere Capping Protein Kinase B Binding TORC2 Signaling Protein Binding Regulation Of Vesicle Size Phagocytic Vesicle TOR Signaling Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cell Fate Specification Positive Regulation Of Cellular Component Organization Telomere Maintenance Protein Stabilization Ruffle Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Cellular Component Size Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Endomembrane System Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Memory T Cell Differentiation Protein Folding Chaperone Complex Epigenetic Programming Of Gene Expression Telomere Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Generation Of Precursor Metabolites And Energy Histone Methyltransferase Activity Positive Regulation Of Biosynthetic Process Response To Hypoxia Negative Regulation Of Macroautophagy
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