RAI2 and CTBP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		RAI2	CTBP2
Gene Name		retinoic acid induced 2	C-terminal binding protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Nucleus Transcriptional Repressor Complex Cell Junction Synapse
	Molecular Function	Molecular_function Protein Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Retinoic Acid Receptor Binding NAD Binding
	Biological Process	Embryo Development	Transcription, DNA-templated Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation Oxidation-reduction Process
Pathways			APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated repression of WNT target genes S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS			Prostate cancer ( 18264096)
Protein-Protein Interactions		7 interactors: APP ATXN1 CTBP1 CTBP2 FHL2 SGTB UBQLN4	67 interactors: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 HIC1 HIST3H3 HOXB5 IKZF1 IKZF2 KLF3 KLF8 LCOR MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RBBP8 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750
Entrez ID		10742	1488
HPRD ID		02199	04016
Ensembl ID		ENSG00000131831	ENSG00000175029
Uniprot IDs		B2RBE9 B3KPD7 Q9Y5P3	P56545 Q5SQP8
PDB IDs			2OME
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Viral Genome Replication Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Visual Learning Visual Behavior Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Associative Learning Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Adult Locomotory Behavior Gene Expression Fat Cell Differentiation Synaptic Growth At Neuromuscular Junction Learning Negative Regulation Of Transcription From RNA Polymerase II Promoter Collateral Sprouting In Absence Of Injury Atrial Cardiac Muscle Cell Development Adult Behavior Viral Life Cycle Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of RNA Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Chromatin Binding Locomotory Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Choice Point Recognition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Binding	RNA Biosynthetic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Viral Process Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Developmental Process Cellular Process Multicellular Organismal Development Muscle Structure Development Muscle Organ Development Organ Development Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Difference) ?			acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Intersection) ?