TESK1 and ABCB4

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TESK1	ABCB4
Name		testis associated actin remodelling kinase 1	ATP binding cassette subfamily B member 4
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Lamellipodium Cytoplasmic Vesicle Cell Projection Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity ABC-type Transporter Activity
	Biological Process	Spermatogenesis Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Nuclear-transcribed MRNA Catabolic Process, No-go Decay Podocyte Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly	Lipid Metabolic Process Lipid Transport Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport
Pathways		Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1
Drugs		Fostamatinib	None
Diseases		None	Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		No GWAS studies recorded	Alanine aminotransferase levels ( 33547301 33339817 ) Alanine transaminase levels ( 29403010 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Epithelial ovarian cancer ( 25134534 ) Gallbladder cancer ( 28274756 ) Gallstone disease ( 30504769 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean reticulocyte volume ( 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Total cholesterol levels ( 30275531 )
Novel Interactors		1 novel interactors: IL17RA	1 novel interactors: PRKAR2B
Interacting Genes		7 interacting genes: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1	3 interacting genes: HAX1 PIGY TESK1
Entrez ID		7016	5244
HPRD ID		03470	01371
Ensembl ID		ENSG00000107140	ENSG00000005471
Uniprot IDs		Q15569 Q8NFJ4	P21439
PDB IDs		Not available	6S7P 7NIU 7NIV 7NIW
GO Terms Enriched among Interactors		Response To Ether Focal Adhesion Cofilin-actin Rod Cellular Response To Interleukin-1 Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge Protein Kinase Inhibitor Activity Response To Interleukin-1 Regulation Of Embryonic Development Negative Regulation Of Developmental Growth Cellular Response To Cytokine Stimulus Ruffle Membrane Negative Regulation Of Postsynaptic Density Organization Response To Fenofibrate Immunoglobulin Heavy Chain V-D-J Recombination Regulation Of Protein Localization To Cell Leading Edge 6-phosphofructokinase Activity Negative Regulation Of Protein Transport 6-phosphofructokinase Complex Cellular Response To Bile Acid Ceramide Floppase Activity Ceramide Translocation Response To Prostaglandin F Interleukin-17 Receptor Activity Nuclear Matrix Response To Peptide Response To Cytokine Neural Fold Formation Actin Filament Fragmentation Fructose-6-phosphate Binding Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Growth Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Lamellipodium Assembly Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphoserine Residue Binding T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Fructose Binding Monosaccharide Binding	Response To Antipsychotic Drug Protein Domain Specific Binding CAMP-dependent Protein Kinase Regulator Activity Podocyte Cell Migration Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Actin Filament Organization Lamellipodium Granulocyte Colony-stimulating Factor Signaling Pathway Interleukin-1 Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Granulocyte Differentiation