TESK1 and PFKL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TESK1	PFKL
Description		testis associated actin remodelling kinase 1	phosphofructokinase, liver type
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Lamellipodium Cytoplasmic Vesicle Cell Projection Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Spermatogenesis Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Nuclear-transcribed MRNA Catabolic Process, No-go Decay Podocyte Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly	Fructose 6-phosphate Metabolic Process Glycolytic Process Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Insulin Secretion Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis
Pathways		Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Neutrophil degranulation Glycolysis
Drugs		Fostamatinib
Diseases
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Rheumatoid arthritis ( 21505073)
Interacting Genes		7 interacting genes: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1	18 interacting genes: APP ATN1 CEBPA COPS6 DNAAF5 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PFKM PRPF40A SHANK3 SUMO2 TESK1 TNFAIP3 USP39 YWHAQ
Entrez ID		7016	5211
HPRD ID		03470	01385
Ensembl ID		ENSG00000107140	ENSG00000141959
Uniprot IDs		Q15569 Q8NFJ4	P17858 Q7L2M7
PDB IDs			7LW1 8W2G 8W2H 8W2I 8W2J
Enriched GO Terms of Interacting Partners?		Response To Ether Focal Adhesion Cofilin-actin Rod Cellular Response To Interleukin-1 Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge Protein Kinase Inhibitor Activity Response To Interleukin-1 Regulation Of Embryonic Development Negative Regulation Of Developmental Growth Cellular Response To Cytokine Stimulus Ruffle Membrane Negative Regulation Of Postsynaptic Density Organization Response To Fenofibrate Immunoglobulin Heavy Chain V-D-J Recombination Regulation Of Protein Localization To Cell Leading Edge 6-phosphofructokinase Activity Negative Regulation Of Protein Transport 6-phosphofructokinase Complex Cellular Response To Bile Acid Ceramide Floppase Activity Ceramide Translocation Response To Prostaglandin F Interleukin-17 Receptor Activity Nuclear Matrix Response To Peptide Response To Cytokine Neural Fold Formation Actin Filament Fragmentation Fructose-6-phosphate Binding Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Growth Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Lamellipodium Assembly Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphoserine Residue Binding T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Fructose Binding Monosaccharide Binding	Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Interleukin-1 Production Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response Memory Cytosol Leukocyte Activation Involved In Inflammatory Response Identical Protein Binding Regulation Of Interleukin-1 Beta Production Kinase Binding Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intermediate Filament Regulation Of Toll-like Receptor 4 Signaling Pathway TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate Tolerance Induction To Lipopolysaccharide Protein Modification By Small Protein Removal Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Macrophage Differentiation Positive Regulation Of Protein Localization Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Proteolysis Positive Regulation Of Defense Response
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