TESK1 and SPRY4

Number of citations of the paper that reports this interaction (PMID 12027893)
16

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TESK1	SPRY4
Gene Name		testis-specific kinase 1	sprouty homolog 4 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Golgi Apparatus Focal Adhesion Ruffle Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	Spermatogenesis Peptidyl-tyrosine Phosphorylation Cell Junction Assembly	Multicellular Organismal Development Negative Regulation Of MAP Kinase Activity
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		7 interactors: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1	3 interactors: RAF1 TESK1 ZDHHC17
Entrez ID		7016	81848
HPRD ID		03470	10466
Ensembl ID		ENSG00000107140	ENSG00000187678
Uniprot IDs		Q15569 Q8NFJ4	Q9C004
PDB IDs			3BUN
Enriched GO Terms of Interacting Partners?			Death-inducing Signaling Complex Assembly
Tagcloud ?		blastema blastemal crabp2 displaying e15 e17 earliest fzd2 grk7 harboring hdgf igf2 interruption kidneys metanephric microdissected originate orthologous p1 p7 recapitulated revealing robustness timp3 triggering triphasic wilms wnt5b wts	antitumoral cadherin characteristically depletion dysregulated ezh2 homolog interference intron intronic it1 lncrna lncrnas mesenchymal noncoding nsclc nude oncogenesis polycomb repression rescued restored rnas silencing suppressors transcript vimentin xenografted zeste
Tagcloud (Difference) ?		blastema blastemal crabp2 displaying e15 e17 earliest fzd2 grk7 harboring hdgf igf2 interruption kidneys metanephric microdissected originate orthologous p1 p7 recapitulated revealing robustness timp3 triggering triphasic wilms wnt5b wts	antitumoral cadherin characteristically depletion dysregulated ezh2 homolog interference intron intronic it1 lncrna lncrnas mesenchymal noncoding nsclc nude oncogenesis polycomb repression rescued restored rnas silencing suppressors transcript vimentin xenografted zeste
Tagcloud (Intersection) ?