TESK1

Name	testis associated actin remodelling kinase 1
Structure	No pdb structure
Novel Interactors	1 novel interactors: IL17RA
Interactors	7 interactors: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Lamellipodium Cytoplasmic Vesicle Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Spermatogenesis Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Nuclear-transcribed MRNA Catabolic Process, No-go Decay Podocyte Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs	Fostamatinib
GWAS	No GWAS studies recorded
Entrez ID	7016
HPRD ID	03470
Ensembl ID	ENSG00000107140
Uniprot IDs	Q15569 Q8NFJ4
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Response To Ether Focal Adhesion Cofilin-actin Rod Cellular Response To Interleukin-1 Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge Protein Kinase Inhibitor Activity Response To Interleukin-1 Regulation Of Embryonic Development Negative Regulation Of Developmental Growth Cellular Response To Cytokine Stimulus Ruffle Membrane Negative Regulation Of Postsynaptic Density Organization Response To Fenofibrate Immunoglobulin Heavy Chain V-D-J Recombination Regulation Of Protein Localization To Cell Leading Edge 6-phosphofructokinase Activity Negative Regulation Of Protein Transport 6-phosphofructokinase Complex Cellular Response To Bile Acid Ceramide Floppase Activity Ceramide Translocation Response To Prostaglandin F Interleukin-17 Receptor Activity Nuclear Matrix Response To Peptide Response To Cytokine Neural Fold Formation Actin Filament Fragmentation Fructose-6-phosphate Binding Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Growth Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Lamellipodium Assembly Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphoserine Residue Binding T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Fructose Binding Monosaccharide Binding