TESK1 and IL17RA

Data Source: HiPPIP (Novel)

		TESK1	IL17RA
Name		testis associated actin remodelling kinase 1	interleukin 17 receptor A
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Lamellipodium Cytoplasmic Vesicle Cell Projection Perinuclear Region Of Cytoplasm	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Protein Serine Kinase Activity	Signaling Receptor Binding Protein Binding Interleukin-17 Receptor Activity
	Biological Process	Spermatogenesis Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Nuclear-transcribed MRNA Catabolic Process, No-go Decay Podocyte Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly	Adaptive Immune Response Immune System Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Virus Protein Catabolic Process Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-17A-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Granulocyte Chemotaxis Fibroblast Activation T-helper 17 Type Immune Response Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Interleukin-17 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Fostamatinib	None
Diseases		None	Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heschl's gyrus morphology ( 25130324 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600 ) White blood cell count ( 27863252 32888494 )
Novel Interactors		1 novel interactors: IL17RA	5 novel interactors: BCL2L13 BID POTEH PTPRT TESK1
Interacting Genes		7 interacting genes: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1	2 interacting genes: IL17A MTDH
Entrez ID		7016	23765
HPRD ID		03470	10399
Ensembl ID		ENSG00000107140	ENSG00000177663
Uniprot IDs		Q15569 Q8NFJ4	Q96F46
PDB IDs		Not available	3JVF 4HSA 4NUX 5N9B 5NAN 7UWL 7UWM 7UWN 7ZAN
GO Terms Enriched among Interactors		Response To Ether Focal Adhesion Cofilin-actin Rod Cellular Response To Interleukin-1 Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge Protein Kinase Inhibitor Activity Response To Interleukin-1 Regulation Of Embryonic Development Negative Regulation Of Developmental Growth Cellular Response To Cytokine Stimulus Ruffle Membrane Negative Regulation Of Postsynaptic Density Organization Response To Fenofibrate Immunoglobulin Heavy Chain V-D-J Recombination Regulation Of Protein Localization To Cell Leading Edge 6-phosphofructokinase Activity Negative Regulation Of Protein Transport 6-phosphofructokinase Complex Cellular Response To Bile Acid Ceramide Floppase Activity Ceramide Translocation Response To Prostaglandin F Interleukin-17 Receptor Activity Nuclear Matrix Response To Peptide Response To Cytokine Neural Fold Formation Actin Filament Fragmentation Fructose-6-phosphate Binding Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Growth Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Lamellipodium Assembly Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphoserine Residue Binding T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Fructose Binding Monosaccharide Binding	None