CTCF and RXRA

Number of citations of the paper that reports this interaction (PubMedID 20404925)
64

Data Source:
BioGRID (pull down, pull down)

		CTCF	RXRA
Description		CCCTC-binding factor	retinoid X receptor alpha
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding Chromatin Loop Anchoring Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Retinoic Acid Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Peptide Binding Identical Protein Binding Nuclear Vitamin D Receptor Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding DNA Binding Domain Binding LBD Domain Binding Vitamin D Response Element Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Chromosome Segregation Heart Development Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Localization To Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region Genomic Imprinting Chromatin Looping	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of DNA-templated Transcription Nervous System Development Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Cell Differentiation Monocyte Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Retinoic Acid Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Lipid Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Cell Maturation Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Low-density Lipoprotein Particle Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Lipoprotein Transport
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	BMAL1:CLOCK,NPAS2 activates circadian expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine shuttle Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Cytoprotection by HMOX1 Heme signaling TGFBR3 expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			alpha-Linolenic acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid EVT-101 3,20-Pregnanedione 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Tributyltin
Diseases
GWAS		Elevated fasting plasma glucose ( 30004843) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 19060911) Hemoglobin levels ( 32327693) Refractive error ( 32231278)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Blood pressure ( 24954895) Central corneal thickness ( 22814818 23493294 28171582 29760442 30894546 31798171) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) HDL cholesterol levels in HIV infection ( 33109212) Intelligence ( 22449649) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		20 interacting genes: CHD1L CHD7 CHD8 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 THRB TRAF2 TRB YBX1 ZMYM4 ZMYM6	119 interacting genes: ACVR1 ACVR1B ALOX15B ARID5A BCL3 BMAL1 BRD8 CASP2 CHD9 CLOCK CNOT1 COPS2 CSNK2B CTCF CTNNB1 CTSL DNMT3L DNTTIP2 EDF1 ESR1 ESRRA FUS GADD45A GADD45G GATA2 GK GRIP1 GSK3B HDAC3 HDAC4 HMGA1 IGFBP3 ITGB3BP JAZF1 JMJD1C KIF1A KLF5 MAPK1 MAPK3 MAPK7 MECR MED1 MED24 MED25 MPG MYOD1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFKB1 NFKBIB NPAS2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2E3 NR2F1 NR2F6 NR3C2 NR4A1 NR4A2 NRBF2 NRIP1 NSD1 PARP1 PLK1 PML POU2F1 POU2F2 PPARA PPARD PPARG PPARGC1A PRKD2 PRMT2 PSMC3IP PSMC5 RAD54L2 RARA RARB RARG RELA RNF8 ROBO4 RPS6KA6 SMAD2 SMARCB1 SMARCD3 SMN1 SNW1 SP1 SRC SRF STAT1 TADA3 TAF11 TAF1B TBP TDG THRA THRB TK1 TMPRSS3 TRIM24 TRIP10 TRIP4 UBE2I UBQLN4 UBR5 VDR ZBTB16 ZNHIT3
Entrez ID		10664	6256
HPRD ID		05005	01577
Ensembl ID		ENSG00000102974	ENSG00000186350
Uniprot IDs		A0A2R8YFL0 P49711	A0A5F9ZHH6 F1D8Q5 P19793 Q6P3U7
PDB IDs		1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL 6QNX 7W1M 8SSQ 8SSR 8SSS 8SST 8SSU	1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6JNO 6JNR 6L6K 6LB4 6LB5 6LB6 6SJM 6STI 6XWG 6XWH 7A77 7B88 7B9O 7BK4 7CFO 7NKE 7UW2 7UW4 8HBM 8PP0
Enriched GO Terms of Interacting Partners?		Chromatin Binding DNA Binding In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Double-stranded DNA Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II ATP-dependent Chromatin Remodeler Activity Chromatin Negative Regulation Of RNA Metabolic Process RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Enzyme Binding Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Thyroid Hormone Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding SMAD Protein Complex Transcription Coactivator Binding Regulation Of Cell Communication Regulation Of Signaling Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction MRNA Transcription Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Cellular Response To Glucose Stimulus Atrioventricular Canal Development MRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Nuclear Receptor Activity Nuclear Retinoid X Receptor Binding Nuclear Receptor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Sequence-specific DNA Binding Nuclear Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-templated Transcription Transcription Coactivator Activity Transcription By RNA Polymerase II Nuclear Thyroid Hormone Receptor Binding Transcription Regulator Complex Nuclear Retinoic Acid Receptor Binding Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Cellular Response To Hormone Stimulus
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