CTCF and RAD51

Number of citations of the paper that reports this interaction (PubMedID 28973861)
40

Data Source:
BioGRID (pull down)

		CTCF	RAD51
Description		CCCTC-binding factor	RAD51 recombinase
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus	Nuclear Ubiquitin Ligase Complex Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Cytosol Cytoskeleton PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Presynaptic Intermediate Filament Cytoskeleton
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding Chromatin Loop Anchoring Activity Sequence-specific Double-stranded DNA Binding	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Chromosome Segregation Heart Development Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Localization To Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region Genomic Imprinting Chromatin Looping	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Metabolic Process DNA Repair DNA Recombination Mitotic Recombination DNA Damage Response Meiosis I Reciprocal Meiotic Recombination Response To Xenobiotic Stimulus Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Telomere Organization Interstrand Cross-link Repair DNA Strand Invasion Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Cellular Response To Alkaloid Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing Double-strand Break Repair Involved In Meiotic Recombination Regulation Of DNA Damage Checkpoint
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS		Elevated fasting plasma glucose ( 30004843) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 19060911) Hemoglobin levels ( 32327693) Refractive error ( 32231278)	Anxiety and stress-related disorders ( 31116379) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		20 interacting genes: CHD1L CHD7 CHD8 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 THRB TRAF2 TRB YBX1 ZMYM4 ZMYM6	99 interacting genes: ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 CASP3 CASP7 CASP8AP2 CCND1 CDH13 CHD3 CHEK1 CRYAA CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FBXO5 FIRRM GMEB1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MCPH1 MDC1 MMS22L MSH4 NBN NCL NELFB NXF1 PARPBP PCSK1N PDS5B PFN1 PIAS1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RAD54L2 RECQL5 RELA RFWD3 RNF20 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TDG TFF1 TOPORS TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17
Entrez ID		10664	5888
HPRD ID		05005	01557
Ensembl ID		ENSG00000102974	ENSG00000051180
Uniprot IDs		A0A2R8YFL0 P49711	Q06609
PDB IDs		1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL 6QNX 7W1M 8SSQ 8SSR 8SSS 8SST 8SSU	1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL 7C9A 7EJC 7EJE 8BQ2 8BR2 8BSC 8GYK 8JND 8JNE 8JNF 8PBC 8PBD 8R64 8RCD 8RCF 8XBT 8XBU 8XBV 8XBW 8XBX 8XBY
Enriched GO Terms of Interacting Partners?		Chromatin Binding DNA Binding In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Double-stranded DNA Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II ATP-dependent Chromatin Remodeler Activity Chromatin Negative Regulation Of RNA Metabolic Process RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Enzyme Binding Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Thyroid Hormone Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding SMAD Protein Complex Transcription Coactivator Binding Regulation Of Cell Communication Regulation Of Signaling Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction MRNA Transcription Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Cellular Response To Glucose Stimulus Atrioventricular Canal Development MRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process	DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair Cellular Response To Stress DNA Recombination Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Macromolecule Metabolic Process Nucleus PML Body Signal Transduction In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Replication Fork Regulation Of Cell Cycle Single-stranded DNA Binding Response To Ionizing Radiation DNA Binding DNA Damage Checkpoint Signaling Response To Radiation Regulation Of DNA Repair Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Chromosome Organization Mitotic DNA Integrity Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Damaged DNA Binding Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Cell Cycle Process Site Of Double-strand Break Homologous Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination
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