CTCF and ZMYM4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CTCF	ZMYM4
Description		CCCTC-binding factor	zinc finger MYM-type containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding Chromatin Loop Anchoring Activity Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Chromosome Segregation Heart Development Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Localization To Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region Genomic Imprinting Chromatin Looping	Cytoskeleton Organization Regulation Of Cell Morphogenesis
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Elevated fasting plasma glucose ( 30004843) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 19060911) Hemoglobin levels ( 32327693) Refractive error ( 32231278)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Monocyte percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		20 interacting genes: CHD1L CHD7 CHD8 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 THRB TRAF2 TRB YBX1 ZMYM4 ZMYM6	10 interacting genes: CTCF FHL2 H3-4 HNRNPD LIMS1 ROR2 RUNX1 RUNX1T1 SRPK2 SUMO2
Entrez ID		10664	9202
HPRD ID		05005	10326
Ensembl ID		ENSG00000102974	ENSG00000146463
Uniprot IDs		A0A2R8YFL0 P49711	Q5VZL5
PDB IDs		1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL 6QNX 7W1M 8SSQ 8SSR 8SSS 8SST 8SSU
Enriched GO Terms of Interacting Partners?		Chromatin Binding DNA Binding In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Double-stranded DNA Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II ATP-dependent Chromatin Remodeler Activity Chromatin Negative Regulation Of RNA Metabolic Process RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Enzyme Binding Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Thyroid Hormone Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding SMAD Protein Complex Transcription Coactivator Binding Regulation Of Cell Communication Regulation Of Signaling Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction MRNA Transcription Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Cellular Response To Glucose Stimulus Atrioventricular Canal Development MRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cardiac Cell Development Cardiac Muscle Cell Development Hepatocyte Dedifferentiation Cellular Response To Putrescine Chromatin Loop Anchoring Activity Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Striated Muscle Cell Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Atrial Cardiac Muscle Cell Development Circadian Regulation Of Translation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Muscle Cell Development Positive Regulation Of Biosynthetic Process Core-binding Factor Complex Negative Regulation Of Metabolic Process Cardiac Muscle Tissue Regeneration Nuclear Speck Organization Spermatogonial Cell Division Chromatin Insulator Sequence Binding Regulation Of Macromolecule Metabolic Process Cellular Developmental Process Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex Regulation Of Centromeric Sister Chromatid Cohesion Response To Rapamycin Cell Dedifferentiation
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