CTCF and CHD8

Number of citations of the paper that reports this interaction (PubMedID 16949368)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CTCF	CHD8
Description		CCCTC-binding factor	chromodomain helicase DNA binding protein 8
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus	Chromatin Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding Chromatin Loop Anchoring Activity Sequence-specific Double-stranded DNA Binding	Nucleotide Binding P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Histone H3K4me3 Reader Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Chromosome Segregation Heart Development Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Localization To Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region Genomic Imprinting Chromatin Looping	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Startle Response Chromatin Organization Chromatin Remodeling MRNA Processing Brain Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Social Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Elevated fasting plasma glucose ( 30004843) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 19060911) Hemoglobin levels ( 32327693) Refractive error ( 32231278)	Appendicular lean mass ( 33097823) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		20 interacting genes: CHD1L CHD7 CHD8 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 THRB TRAF2 TRB YBX1 ZMYM4 ZMYM6	12 interacting genes: AR CEBPA CHD7 CREB1 CTCF CTNNB1 MYC RBBP5 RCHY1 SUMO2 TOP3B WDR5
Entrez ID		10664	57680
HPRD ID		05005	16712
Ensembl ID		ENSG00000102974	ENSG00000100888
Uniprot IDs		A0A2R8YFL0 P49711	Q9HCK8
PDB IDs		1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL 6QNX 7W1M 8SSQ 8SSR 8SSS 8SST 8SSU	2CKA 2DL6
Enriched GO Terms of Interacting Partners?		Chromatin Binding DNA Binding In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Double-stranded DNA Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II ATP-dependent Chromatin Remodeler Activity Chromatin Negative Regulation Of RNA Metabolic Process RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Enzyme Binding Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Thyroid Hormone Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding SMAD Protein Complex Transcription Coactivator Binding Regulation Of Cell Communication Regulation Of Signaling Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction MRNA Transcription Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Cellular Response To Glucose Stimulus Atrioventricular Canal Development MRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process	DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Centromeric Sister Chromatid Cohesion Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Euchromatin Chromatin Binding Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of DNA-templated Transcription Initiation MLL1/2 Complex In Utero Embryonic Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Chordate Embryonic Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Genitalia Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression MLL3/4 Complex Regulation Of Fibroblast Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
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