LBX1 and EIF5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LBX1	EIF5A
Description		ladybird homeobox 1	eukaryotic translation initiation factor 5A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Synapse
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding
	Biological Process	Heart Looping Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Cell Differentiation Neuron Fate Commitment Neuron Fate Determination Negative Regulation Of Glutamatergic Neuron Differentiation Glutamatergic Neuron Differentiation	Translation Translational Elongation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26211971 30395268 31417091) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779) Severe insulin-resistant type 2 diabetes ( 34737425)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Venous thromboembolism ( 31420334)
Interacting Genes		23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483	19 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP SENP1 STUB1 SUMO2 TGM2 UBE2I XPO1 XPO4 XRN2
Entrez ID		10660	1984
HPRD ID		09178	02555
Ensembl ID		ENSG00000138136	ENSG00000132507
Uniprot IDs		P52954	P63241
PDB IDs			3CPF 5DLQ 8A0E 8Y0W
Enriched GO Terms of Interacting Partners?			Regulation Of Ubiquitin-dependent Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Export Signal Receptor Activity Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Nucleus Nuclear Export DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Deoxyhypusine Synthase Activity Focal Adhesion Interleukin-5 Receptor Complex Regulation Of Protein Catabolic Process Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Monoamine Transport Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of Protein Export From Nucleus Protein Export From Nucleus Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Glutamatergic Neuron Differentiation Peptidyl-lysine Modification To Peptidyl-hypusine Deoxyhypusine Monooxygenase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Spermidine Catabolic Process Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interleukin-5 Receptor Binding Protein Deamination Cellular Response To Triglyceride Transcription Termination Site Sequence-specific DNA Binding Nuclear Transport Nucleocytoplasmic Transport
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