LBX1 and WNK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LBX1	WNK3
Description		ladybird homeobox 1	WNK lysine deficient protein kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytoplasm Adherens Junction Bicellular Tight Junction
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transmembrane Transporter Binding Protein Serine Kinase Activity Molecular Condensate Scaffold Activity Transporter Activator Activity
	Biological Process	Heart Looping Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Cell Differentiation Neuron Fate Commitment Neuron Fate Determination Negative Regulation Of Glutamatergic Neuron Differentiation Glutamatergic Neuron Differentiation	Protein Phosphorylation Cell Volume Homeostasis DNA Damage Response Osmosensory Signaling Pathway Positive Regulation Of Sodium Ion Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Maintenance Of Blood-brain Barrier Negative Regulation Of Apoptotic Process Monoatomic Ion Homeostasis Positive Regulation Of Calcium Ion Transport Renal Sodium Ion Absorption Cellular Hyperosmotic Response Protein Localization To Plasma Membrane Negative Regulation Of Pancreatic Juice Secretion Regulation Of Calcium Ion Import Membraneless Organelle Assembly Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26211971 30395268 31417091) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779) Severe insulin-resistant type 2 diabetes ( 34737425)	Height ( 28552196)
Interacting Genes		23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483	4 interacting genes: KLHL3 LBX1 REL TSC22D2
Entrez ID		10660	65267
HPRD ID		09178	02289
Ensembl ID		ENSG00000138136	ENSG00000196632
Uniprot IDs		P52954	Q9BYP7
PDB IDs			5NKP 5O1V 5O21 5O23 5O26 5O2B 5O2C 8EDH 9D7Q
Enriched GO Terms of Interacting Partners?			Epithelial Tube Morphogenesis Negative Regulation Of Glutamatergic Neuron Differentiation Distal Tubule Morphogenesis NF-kappaB Complex
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