LBX1 and ZNF483

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LBX1	ZNF483
Description		ladybird homeobox 1	zinc finger protein 483
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Heart Looping Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Cell Differentiation Neuron Fate Commitment Neuron Fate Determination Negative Regulation Of Glutamatergic Neuron Differentiation Glutamatergic Neuron Differentiation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26211971 30395268 31417091) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779) Severe insulin-resistant type 2 diabetes ( 34737425)	Age at voice drop ( 27182965) Apolipoprotein A1 levels ( 32203549) Height ( 31562340) Menarche (age at onset) ( 21102462 23599027 25231870 27182965) Pubertal anthropometrics ( 23449627)
Interacting Genes		23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483	11 interacting genes: APP CAMTA2 CRX ECPAS LBX1 MEOX2 TRIM69 USHBP1 ZKSCAN4 ZSCAN21 ZSCAN22
Entrez ID		10660	158399
HPRD ID		09178	18345
Ensembl ID		ENSG00000138136	ENSG00000173258
Uniprot IDs		P52954	Q6P088 Q8TF39
PDB IDs			2CTU
Enriched GO Terms of Interacting Partners?			DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleus Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Negative Regulation Of Glutamatergic Neuron Differentiation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Gene Expression Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Chromatin Binding Astrocyte Activation Involved In Immune Response Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Somite Specification Positive Regulation Of RNA Metabolic Process Chromatin Regulation Of Spontaneous Synaptic Transmission
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