LBX1 and FAM221B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LBX1	FAM221B
Description		ladybird homeobox 1	family with sequence similarity 221 member B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Heart Looping Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Cell Differentiation Neuron Fate Commitment Neuron Fate Determination Negative Regulation Of Glutamatergic Neuron Differentiation Glutamatergic Neuron Differentiation
Pathways
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26211971 30395268 31417091) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779) Severe insulin-resistant type 2 diabetes ( 34737425)	Multiple sclerosis ( 31604244)
Interacting Genes		23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483	14 interacting genes: ANKRD11 CCDC13 CYSRT1 EFHC2 GSC2 KPRP KRT35 KRTAP10-8 KRTAP13-1 LBX1 LCE2C LZTS2 PLSCR2 TRIM50
Entrez ID		10660	392307
HPRD ID		09178	16675
Ensembl ID		ENSG00000138136	ENSG00000204930
Uniprot IDs		P52954	A6H8Z2
PDB IDs
Enriched GO Terms of Interacting Partners?			Keratin Filament Intermediate Filament Epidermis Development Establishment Of Skin Barrier Skin Epidermis Development Negative Regulation Of Glutamatergic Neuron Differentiation Primary Ureteric Bud Growth
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