LBX1 and AIPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LBX1	AIPL1
Description		ladybird homeobox 1	AIP like 1 HSP90 co-chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Farnesylated Protein Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Unfolded Protein Binding
	Biological Process	Heart Looping Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Cell Differentiation Neuron Fate Commitment Neuron Fate Determination Negative Regulation Of Glutamatergic Neuron Differentiation Glutamatergic Neuron Differentiation	Retina Homeostasis Apoptotic Process Visual Perception Phototransduction, Visible Light Protein Farnesylation Regulation Of Opsin-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases			Leber congenital amaurosis (LCR)
GWAS		Adolescent idiopathic scoliosis ( 26211971 30395268 31417091) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779) Severe insulin-resistant type 2 diabetes ( 34737425)	C-reactive protein levels ( 29403010 33339817) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hormone measurements ( 23696881) Manganese levels ( 26025379) Paclitaxel-induced cytotoxicity ( 26015512) Reading disability ( 32108986)
Interacting Genes		23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483	10 interacting genes: ACD HSP90AA1 HSPA8 LBX1 NUB1 PLSCR3 POT1 SMAP1 TINF2 TXNL4B
Entrez ID		10660	23746
HPRD ID		09178	05092
Ensembl ID		ENSG00000138136	ENSG00000129221
Uniprot IDs		P52954	F1T0B5 F1T0B6 F1T0C0 F1T0C4 Q7Z3H1 Q9NZN9
PDB IDs			5U9A 5U9I 5U9J 5U9K 5V35 6PX0
Enriched GO Terms of Interacting Partners?			Telomere Assembly Shelterin Complex Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Capping Positive Regulation Of Telomere Maintenance Regulation Of DNA Biosynthetic Process Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Regulation Of Telomere Maintenance Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Chaperone-mediated Autophagy Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Organelle Chromosome Organization Negative Regulation Of DNA Metabolic Process DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase MHC Class II Protein Complex Binding Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Protein Refolding Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Positive Regulation Of Organelle Organization Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Regulation Of Organelle Organization Positive Regulation Of DNA Biosynthetic Process Protein Localization To Organelle Nucleic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Chaperone-mediated Autophagy Translocation Complex Disassembly Protein Folding Chaperone DNA Metabolic Process
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