SLC22A2 and LSM4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SLC22A2	LSM4
Description		solute carrier family 22 member 2	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extracellular Exosome Presynapse	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol Membrane Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	Amine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity	RNA Binding Protein Binding U6 SnRNA Binding PH Domain Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Neurotransmitter Transport Serotonin Transport Body Fluid Secretion Organic Cation Transport Quaternary Ammonium Group Transport Prostaglandin Transport Amine Transport Putrescine Transport Spermidine Transport Acetylcholine Transport Choline Transport Dopamine Transport Norepinephrine Transport Xenobiotic Transport Epinephrine Transport Histamine Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Transmembrane Transport Thiamine Transmembrane Transport Purine-containing Compound Transmembrane Transport Amino Acid Import Across Plasma Membrane Dopamine Uptake L-arginine Import Across Plasma Membrane Export Across Plasma Membrane Transport Across Blood-brain Barrier L-alpha-amino Acid Transmembrane Transport Spermidine Transmembrane Transport L-arginine Transmembrane Transport Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process RNA Processing MRNA Processing RNA Splicing P-body Assembly
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport SLC-mediated transport of neurotransmitters SLC-mediated transport of organic cations	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		A body shape index ( 34021172) Body mass index ( 25673413 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic kidney disease ( 20383146 31152163) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31451708 31152163 31015462 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hip circumference adjusted for BMI ( 34021172) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Chronotype ( 30696823) Estimated glomerular filtration rate ( 30604766) Gastroesophageal reflux disease ( 31527586) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 32888494)
Interacting Genes		45 interacting genes: AGO3 CCL2 CD63 CD9 CLPTM1 CST9L CYB5R3 DPM2 EEF1G ETV5 FAIM2 FIS1 FXYD2 FZD5 GTF2B HNRNPH3 HRCT1 HYAL3 ITM2C KRTCAP2 LAPTM4A LAPTM4B LAPTM5 LSM4 NCOA3 PDIA6 PDZK1IP1 POU2AF1 PRPF8 RPN2 SERP1 SLC40A1 SLC47A2 SNCA SPCS1 STX8 SUMO2 TMEM134 TMEM147 TMEM161A TMEM176B TMEM41B TMX2 TREX1 VKORC1	21 interacting genes: CALCOCO2 COX5B EXOSC8 GAS7 HOMEZ IKZF1 L3MBTL3 NMI PLEKHA5 PSTPIP1 RHOXF2 SLC22A2 SMIM14 SMN1 SMU1 SNRPE TOE1 TOP1 UBC XRN1 ZBTB10
Entrez ID		6582	25804
HPRD ID		04008	06284
Ensembl ID		ENSG00000112499	ENSG00000130520
Uniprot IDs		O15244	Q9Y4Z0 U3KQK1
PDB IDs		8ET9	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Oligosaccharyltransferase Complex Regulation Of Lysosomal Membrane Permeability Endoplasmic Reticulum Membrane Multivesicular Body, Internal Vesicle Response To Peptide	Nucleoplasm SMN-Sm Protein Complex RRNA Catabolic Process Nuclear MRNA Surveillance Precatalytic Spliceosome SnRNA 3'-end Processing
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