SLC22A2 and AGO3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SLC22A2	AGO3
Gene Name		solute carrier family 22 (organic cation transporter), member 2	argonaute RISC catalytic component 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Extracellular Vesicular Exosome	Cytoplasmic MRNA Processing Body Cytosol Membrane RISC Complex Micro-ribonucleoprotein Complex
	Molecular Function	Steroid Binding Organic Cation Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity	Protein Binding MiRNA Binding Poly(A) RNA Binding
	Biological Process	Drug Transmembrane Transport Synaptic Transmission Neurotransmitter Secretion Body Fluid Secretion Organic Cation Transport Quaternary Ammonium Group Transport Choline Transport Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Small Molecule Metabolic Process Histamine Transport Transmembrane Transport	MRNA Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Posttranscriptional Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Stem Cell Proliferation
Pathways		Na+/Cl- dependent neurotransmitter transporters Neurotransmitter Release Cycle Neurotransmitter Clearance In The Synaptic Cleft Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport Abacavir transport and metabolism Transmission across Chemical Synapses	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145)
Protein-Protein Interactions		9 interactors: AGO3 CST9L ETV5 EXT2 GTF2B HYAL3 LSM4 POU2AF1 SUMO2	4 interactors: ATP4B ATP6V0D2 BDNF SLC22A2
Entrez ID		6582	192669
HPRD ID		04008	09558
Ensembl ID		ENSG00000112499	ENSG00000126070
Uniprot IDs		O15244	B4E1P5 Q9H9G7
PDB IDs
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process MRNA Catabolic Process Male Germ-line Stem Cell Asymmetric Division Glycosaminoglycan Metabolic Process RNA Catabolic Process Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Cellular Response To UV-B Skeletal Muscle Acetylcholine-gated Channel Clustering RNA Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Translation Involved In Gene Silencing By MiRNA	Ion Transport Monovalent Inorganic Cation Transport Response To Anesthetic Response To Fluoxetine Response To L-glutamate Response To Organonitrogen Compound Cation Transmembrane Transport Hydrogen Ion Transmembrane Transport Taste Bud Development Regulation Of Retinal Cell Programmed Cell Death Dendrite Extension Cellular Response To Norepinephrine Stimulus Cation Transport Proton Transport Ion Transmembrane Transport Axon Target Recognition Response To Norepinephrine Response To Ether Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Synaptic Transmission, GABAergic Choline Transport Response To Potassium Ion Transmembrane Transport Transport Regulation Of Short-term Neuronal Synaptic Plasticity Response To Light Intensity Chronic Inflammatory Response Cellular Response To Organonitrogen Compound Neurotransmitter Biosynthetic Process Secretion By Cell Response To Drug Histamine Transport Quaternary Ammonium Group Transport Response To Auditory Stimulus Synaptic Transmission Response To Food Glutamate Secretion Secretion Cellular Response To Catecholamine Stimulus Response To Organic Substance Anion Transport Cellular Response To Nerve Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Vitamin A Negative Regulation Of Neuroblast Proliferation Neurotransmitter Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Transferrin Transport Drug Transmembrane Transport
Tagcloud ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 ggt1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc47a1 wu	aberrant ago4 biogenesis cancerous carcinogenesis cigarette combinations components deregulation dgcr8 dicer encodes etiological hbv hcc hepatocarcinogenesis hepatocellular implicated integrated mirna multicentric occurrence p68 p72 paired piwil4 prognosis promoters trimethylation
Tagcloud (Difference) ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 ggt1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc47a1 wu	aberrant ago4 biogenesis cancerous carcinogenesis cigarette combinations components deregulation dgcr8 dicer encodes etiological hbv hcc hepatocarcinogenesis hepatocellular implicated integrated mirna multicentric occurrence p68 p72 paired piwil4 prognosis promoters trimethylation
Tagcloud (Intersection) ?