SLC22A2 and ETV5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SLC22A2	ETV5
Gene Name		solute carrier family 22 (organic cation transporter), member 2	ets variant 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Steroid Binding Organic Cation Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding
	Biological Process	Drug Transmembrane Transport Synaptic Transmission Neurotransmitter Secretion Body Fluid Secretion Organic Cation Transport Quaternary Ammonium Group Transport Choline Transport Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Small Molecule Metabolic Process Histamine Transport Transmembrane Transport	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Neuromuscular Synaptic Transmission Locomotory Behavior Cell Differentiation Cellular Response To Oxidative Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Male Germ-line Stem Cell Asymmetric Division Regulation Of Synapse Organization Positive Regulation Of Glial Cell Proliferation Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Na+/Cl- dependent neurotransmitter transporters Neurotransmitter Release Cycle Neurotransmitter Clearance In The Synaptic Cleft Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport Abacavir transport and metabolism Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145)	Body mass index ( 23563607 19079260 20935630) Menarche (age at onset) ( 21102462) Obesity ( 23563607) Weight ( 19079260)
Protein-Protein Interactions		9 interactors: AGO3 CST9L ETV5 EXT2 GTF2B HYAL3 LSM4 POU2AF1 SUMO2	11 interactors: AMH APP AR BRCA1 CCR5 CISH CYP3A5 DHRS7 HOXD9 SEZ6L2 SLC22A2
Entrez ID		6582	2119
HPRD ID		04008	09035
Ensembl ID		ENSG00000112499	ENSG00000244405
Uniprot IDs		O15244	P41161
PDB IDs
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process MRNA Catabolic Process Male Germ-line Stem Cell Asymmetric Division Glycosaminoglycan Metabolic Process RNA Catabolic Process Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Cellular Response To UV-B Skeletal Muscle Acetylcholine-gated Channel Clustering RNA Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Translation Involved In Gene Silencing By MiRNA	Regulation Of Transcription From RNA Polymerase III Promoter Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Intracellular Steroid Hormone Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Positive Regulation Of Histone H3-K9 Acetylation Preantral Ovarian Follicle Growth Adult Locomotory Behavior Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Histone H4 Acetylation Alkaloid Catabolic Process Negative Regulation Of Histone H3-K4 Methylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Reproductive Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Cytokine Stimulus Regulation Of Integrin Biosynthetic Process Cell Growth Cellular Response To Indole-3-methanol Collateral Sprouting Axon Midline Choice Point Recognition Response To Organic Substance Adult Behavior Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Signaling Response To Cytokine Cell Communication Dosage Compensation By Inactivation Of X Chromosome Axon Choice Point Recognition Oogenesis Stage Positive Regulation Of Cellular Biosynthetic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Protein K6-linked Ubiquitination Gonadal Mesoderm Development Mullerian Duct Regression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Histone H3-K9 Methylation
Tagcloud ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 ggt1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc47a1 wu	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated exhibits fbln1 filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Difference) ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 ggt1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc47a1 wu	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated exhibits fbln1 filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Intersection) ?