CCT2 and GLI1

Number of citations of the paper that reports this interaction (PubMedID 31462707)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CCT2	GLI1
Description		chaperonin containing TCP1 subunit 2	GLI family zinc finger 1
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GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Extracellular Region Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Azurophil Granule Lumen Cell Body Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Axoneme Ciliary Basal Body Ciliary Tip Ciliary Base GLI-SUFU Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Microtubule Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Chaperone-mediated Protein Complex Assembly ScaRNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Spermatid Development Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Anatomical Structure Morphogenesis Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Cerebellar Cortex Morphogenesis Pituitary Gland Development Cell Differentiation Lung Development Positive Regulation Of Cell Migration Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS		Height ( 18391951) Logical memory (delayed recall) in normal cognition ( 29274321) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		27 interacting genes: ACTA1 ACTB AKT1 CEBPA ERLIN2 ESR1 FCHSD2 GABARAP GABARAPL1 GLI1 HSP90AB1 LCOR LINC00624 LINC01554 NPSR1 OGT PRPF40A PSMC6 PSMD2 PTEN RPS3 SUMO2 SUMO4 VAV2 VRK2 YWHAG ZNRD2	22 interacting genes: AQP1 CATSPER1 CCT2 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT1 PRMT5 RAI1 RUNX3 STK36 SUFU TAF9 TRIM42 WDR77 XBP1 ZIC1 ZIC2
Entrez ID		10576	2735
HPRD ID		06895	01311
Ensembl ID		ENSG00000166226	ENSG00000111087
Uniprot IDs		P78371 V9HW96	B4DNF7 P08151
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	2GLI 4BLB 4KMD 5OM0 7T91
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Regulator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Protein Ubiquitination Positive Regulation Of Deoxyribonuclease Activity Protein-containing Complex Positive Regulation Of Protein Catabolic Process Kinase Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Nitric Oxide Metabolic Process Cytoplasmic Translation Regulation Of Protein Modification Process Cellular Response To Nutrient Levels Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Kinase Binding Positive Regulation Of Biosynthetic Process Response To Stress Response To Nutrient Levels Regulation Of Protein Localization To Cell Periphery Ubiquitin Protein Ligase Binding Mitophagy Tat Protein Binding Cellular Response To Nitrogen Starvation Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Localization To Membrane Positive Regulation Of TORC1 Signaling Regulation Of Nitric Oxide Metabolic Process TORC1 Signaling Proteasome Regulatory Particle, Base Subcomplex Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Catabolic Process Negative Regulation Of Translation Cellular Response To Starvation	Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Methylosome Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smoothened Signaling Pathway Methyl-CpG Binding Protein Serine/threonine/tyrosine Kinase Activity Protein Localization To Lipid Droplet Positive Regulation Of Metabolic Process Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Splicing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Protein Transport Developmental Process Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Nucleoplasm Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Protein Phosphorylation Protein Metabolic Process Protein Serine Kinase Activity Cellular Response To Glucose Stimulus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Import Into Nucleus TORC1 Signaling Regulation Of Gene Expression Regulation Of RNA Splicing Negative Regulation Of TORC1 Signaling Nucleotide-activated Protein Kinase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytoplasm Phosphorylation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Carbohydrate Stimulus Negative Regulation Of Developmental Process Protein Serine/threonine Kinase Activity
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