CCT2 and FCHSD2

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		CCT2	FCHSD2
Description		chaperonin containing TCP1 subunit 2	FCH and double SH3 domains 2
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GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Extracellular Region Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Azurophil Granule Lumen Cell Body Extracellular Exosome	Cytoplasm Plasma Membrane Clathrin-coated Pit Membrane Neuromuscular Junction Stereocilium Cell Projection Recycling Endosome Anchoring Junction Stereocilium Shaft
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Chaperone-mediated Protein Complex Assembly ScaRNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Endocytosis Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Membrane Organization Clathrin-dependent Endocytosis Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Height ( 18391951) Logical memory (delayed recall) in normal cognition ( 29274321) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	Albumin-globulin ratio ( 29403010) Crohn's disease ( 23266558 23850713) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Nicotine dependence symptom count ( 25555482) Serum total protein levels ( 29403010) Systemic lupus erythematosus ( 26663301 33272962)
Interacting Genes		27 interacting genes: ACTA1 ACTB AKT1 CEBPA ERLIN2 ESR1 FCHSD2 GABARAP GABARAPL1 GLI1 HSP90AB1 LCOR LINC00624 LINC01554 NPSR1 OGT PRPF40A PSMC6 PSMD2 PTEN RPS3 SUMO2 SUMO4 VAV2 VRK2 YWHAG ZNRD2	52 interacting genes: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CIMIP6 CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587
Entrez ID		10576	9873
HPRD ID		06895	13321
Ensembl ID		ENSG00000166226	ENSG00000137478
Uniprot IDs		P78371 V9HW96	O94868
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	2DL5 2DL7 6GBU
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Regulator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Protein Ubiquitination Positive Regulation Of Deoxyribonuclease Activity Protein-containing Complex Positive Regulation Of Protein Catabolic Process Kinase Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Nitric Oxide Metabolic Process Cytoplasmic Translation Regulation Of Protein Modification Process Cellular Response To Nutrient Levels Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Kinase Binding Positive Regulation Of Biosynthetic Process Response To Stress Response To Nutrient Levels Regulation Of Protein Localization To Cell Periphery Ubiquitin Protein Ligase Binding Mitophagy Tat Protein Binding Cellular Response To Nitrogen Starvation Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Localization To Membrane Positive Regulation Of TORC1 Signaling Regulation Of Nitric Oxide Metabolic Process TORC1 Signaling Proteasome Regulatory Particle, Base Subcomplex Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Catabolic Process Negative Regulation Of Translation Cellular Response To Starvation	TPR Domain Binding Clathrin-dependent Synaptic Vesicle Endocytosis Cytoplasm
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