PRDX4 and MT-CO1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PRDX4	MT-CO1
Name		peroxiredoxin 4	cytochrome c oxidase subunit I
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity	Cytochrome-c Oxidase Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation	Response To Hypoxia Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Oxidative Stress Aerobic Respiration Cerebellum Development Respiratory Electron Transport Chain Cellular Respiration Response To Copper Ion Response To Electrical Stimulus Proton Transmembrane Transport
Pathways		Neutrophil degranulation	Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly
Drugs		None	Cholic Acid N-Formylmethionine Oxygen
Diseases		None	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN	11 interacting genes: CDC42 CLEC4G COX4I1 COX5A DLG4 HSPB2 KCNMB1 LIG4 MEOX2 PRDX4 SNCA
Entrez ID		10549	4512
HPRD ID		05935	02469
Ensembl ID		ENSG00000123131	ENSG00000198804
Uniprot IDs		Q13162 V9HW63	P00395 U5YWV7
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY	5Z62
GO Terms Enriched among Interactors		Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin	Dendritic Spine Morphogenesis Electron Transport Chain Respiratory Chain Complex IV Respiratory Electron Transport Chain Mitochondrial Electron Transport, Cytochrome C To Oxygen Cytochrome-c Oxidase Activity Response To Metal Ion Oxidative Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Dendritic Spine Organization Cellular Response To Metal Ion Positive Regulation Of Cellular Component Organization Neuron Projection Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Postsynapse Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Postsynapse P2Y1 Nucleotide Receptor Binding Establishment Of Integrated Proviral Latency JUN Phosphorylation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Virus Coreceptor Activity Regulation Of Neuronal Synaptic Plasticity GBD Domain Binding Storage Vacuole Regulation Of Endocytosis Mitochondrial Intermembrane Space Generation Of Precursor Metabolites And Energy Aerobic Electron Transport Chain Chemical Synaptic Transmission Voltage-gated Potassium Channel Complex Enzyme Activator Activity Establishment Of Viral Latency Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Periphery Endothelin Receptor Signaling Pathway Involved In Heart Process Aerobic Respiration Protein Phosphatase Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Trans-synaptic Signaling Synaptic Signaling DNA Ligase (ATP) Activity DNA Ligase IV Complex