PRDX4 and CFHR3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PRDX4	CFHR3
Gene Name		peroxiredoxin 4	complement factor H-related 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Smooth Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome	Extracellular Space Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity Protein Homodimerization Activity
	Biological Process	I-kappaB Phosphorylation Spermatogenesis Male Gonad Development 4-hydroxyproline Metabolic Process Protein Maturation By Protein Folding Extracellular Matrix Organization Cell Redox Homeostasis Oxidation-reduction Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Male Germ Cell Proliferation
Pathways			Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23536807) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)
Protein-Protein Interactions		24 interactors: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 COX1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 VTN	2 interactors: C3 PRDX4
Entrez ID		10549	10878
HPRD ID		05935	05626
Ensembl ID		ENSG00000123131	ENSG00000116785
Uniprot IDs		Q13162	Q02985 Q6NSD3
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS
Enriched GO Terms of Interacting Partners?		Hydrogen Peroxide Catabolic Process Cellular Response To Reactive Oxygen Species Response To Stress Hydrogen Peroxide Metabolic Process Immune System Process Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Response To Oxidative Stress Response To Inorganic Substance Catabolic Process Reactive Oxygen Species Metabolic Process Defense Response Removal Of Superoxide Radicals Response To Lipopolysaccharide Cellular Response To Superoxide Response To Molecule Of Bacterial Origin Xenobiotic Metabolic Process Negative Regulation Of Proteolysis Cellular Response To Xenobiotic Stimulus Response To Superoxide Response To Oxygen Radical Regulation Of Proteolysis Response To Xenobiotic Stimulus Negative Regulation Of Protein Processing Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Processing Response To Stimulus Bile Acid Metabolic Process Blood Coagulation Hemostasis Superoxide Metabolic Process Platelet Activation Innate Immune Response Cell Migration Positive Regulation Of Wound Healing Response To Lipid Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Thromboxane A2 Signaling Pathway Hsp90 Deacetylation Immune Response Response To Bacterium Carbohydrate Derivative Transport Leukocyte Migration Negative Regulation Of Blood Coagulation Cell Motility Negative Regulation Of Coagulation Steroid Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels	Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Regulation Of Male Germ Cell Proliferation Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Hypersensitivity Monocarboxylic Acid Metabolic Process Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Protein Maturation By Protein Folding Regulation Of Apoptotic Cell Clearance Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus I-kappaB Phosphorylation Positive Regulation Of Humoral Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process 4-hydroxyproline Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Acute Inflammatory Response Organic Acid Metabolic Process Regulation Of Complement Activation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Lipid Storage Regulation Of Triglyceride Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Protein Maturation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Positive Regulation Of Glucose Transport Regulation Of Humoral Immune Response I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lipid Storage Regulation Of Phagocytosis Regulation Of Acute Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Glucose Transport Positive Regulation Of Endocytosis Reactive Oxygen Species Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Positive Regulation Of Angiogenesis Complement Activation, Classical Pathway Regulation Of Lipid Biosynthetic Process Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Positive Regulation Of Adaptive Immune Response Male Gonad Development Protein Activation Cascade Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Tagcloud ?		1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize	acquiring arguing attachment c3 c5 cfhr1 cfhr2 cfhr4a complement convertase evade expense fba fhl hemolytic heparin m28 m55 m6 scl1 scl2 scr18 scr3 scr7 serotypes streptococcal streptococci uremic utilize
Tagcloud (Difference) ?		1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes	acquiring arguing attachment c3 c5 cfhr1 cfhr2 cfhr4a complement convertase evade expense fba fhl hemolytic heparin m28 m55 m6 scl1 scl2 scr18 scr3 scr7 serotypes streptococcal streptococci uremic
Tagcloud (Intersection) ?		utilize