PRDX4 and A1BG

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PRDX4	A1BG
Name		peroxiredoxin 4	alpha-1-B glycoprotein
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity	None
	Biological Process	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation	Immune Response-regulating Signaling Pathway
Pathways		Neutrophil degranulation	Platelet degranulation Neutrophil degranulation
Drugs		None	Zinc Copper Zinc acetate
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN	13 interacting genes: ABCC6 ANXA7 CDKN1A CRISP3 GRB7 HSP90AA1 MTX1 PRDX4 SAMM50 SETD7 SMN1 SNCA TK1
Entrez ID		10549	1
HPRD ID		05935	00726
Ensembl ID		ENSG00000123131	ENSG00000121410
Uniprot IDs		Q13162 V9HW63	P04217
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY	Not available
GO Terms Enriched among Interactors		Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin	Establishment Of Protein Localization To Mitochondrion SAM Complex MIB Complex Protein Insertion Into Mitochondrial Outer Membrane Response To Magnesium Ion Mitochondrial Membrane Organization Establishment Of Protein Localization To Organelle Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Kinase Inhibitor Activity Protein Sequestering Activity Response To Cocaine Protein Localization To Mitochondrion Tau Protein Binding Inner Mitochondrial Membrane Organization Mitochondrial Outer Membrane CTP Binding DATP Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Membrane Organization Response To Xenobiotic Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Identical Protein Binding Protein Transmembrane Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Protein Insertion Into Membrane Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Thymidine Kinase Activity Response To Metal Ion Regulation Of DNA Biosynthetic Process Response To Alkaloid DNA Biosynthetic Process Rho GDP-dissociation Inhibitor Binding Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Protein Tetramerization Negative Regulation Of Chaperone-mediated Autophagy DNA Synthesis Involved In Mitotic DNA Replication