PRDX4 and TNFRSF8

Data Source: HiPPIP (Novel)

		PRDX4	TNFRSF8
Name		peroxiredoxin 4	TNF receptor superfamily member 8
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleoplasm Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity	Protease Binding Transmembrane Signaling Receptor Activity
	Biological Process	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways		Neutrophil degranulation	TNFs bind their physiological receptors
Drugs		None	Iratumumab XmAb 2513 Brentuximab vedotin
GWAS		No GWAS studies recorded	Asthma ( 31959851 32296059 34103634 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Mosquito bite size ( 28199695 ) Neutrophil percentage of granulocytes ( 27863252 ) Serum alkaline phosphatase levels ( 33339817 ) Sum eosinophil basophil counts ( 27863252 ) Tuberculosis ( 29036319 )
Novel Interactors		1 novel interactors: TNFRSF8	7 novel interactors: CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 WRAP73
Interacting Genes		27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN	7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		10549	943
HPRD ID		05935	01074
Ensembl ID		ENSG00000123131	ENSG00000120949
Uniprot IDs		Q13162 V9HW63	A5D8T4 P28908
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY	1D01
GO Terms Enriched among Interactors		Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Cytokine-mediated Signaling Pathway Signal Transduction Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Receptor Complex Apoptotic Process Response To Environmental Enrichment Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Death Notochord Cell Development Programmed Cell Death TORC2 Complex Disassembly MWP Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Stabilization Swimming Behavior Axial Mesoderm Formation Response To Ketamine TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Receptor Signaling Protein Tyrosine Kinase Activator Activity Core-binding Factor Complex Negative Regulation Of Lymphangiogenesis Notochord Formation I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Protein Phosphorylation