PRDX4 and CYP27A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PRDX4	CYP27A1
Description		peroxiredoxin 4	cytochrome P450 family 27 subfamily A member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Vitamin D3 25-hydroxylase Activity Cholesterol 26-hydroxylase Activity Metal Ion Binding Cholestanetetraol 26-dehydrogenase Activity
	Biological Process	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process Cholesterol Catabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Small Molecule Biosynthetic Process
Pathways		Neutrophil degranulation	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Endogenous sterols Defective CYP27A1 causes CTX
Drugs
Diseases			Cerebrotendinous xanthomatosis; Van Bogaert-Scherer-Epstein Disease
GWAS			Diastolic blood pressure ( 30224653) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) Male-pattern baldness ( 28196072) Reticulocyte count ( 27863252)
Interacting Genes		27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN	2 interacting genes: MTDH PRDX4
Entrez ID		10549	1593
HPRD ID		05935	05939
Ensembl ID		ENSG00000123131	ENSG00000135929
Uniprot IDs		Q13162 V9HW63	Q02318
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY
Enriched GO Terms of Interacting Partners?		Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin	Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity Regulation Of Male Germ Cell Proliferation Intercellular Canaliculus RNA Exonuclease Activity, Producing 5'-phosphomonoesters 5'-3' RNA Exonuclease Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Regulation Of Telomerase RNA Localization To Cajal Body Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Molecular Sequestering Activity Positive Regulation Of Catabolic Process MRNA Methylguanosine-cap Decapping Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Hydrogen Peroxide Catabolic Process RNA Decapping Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Antioxidant Activity Histone MRNA Metabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process NF-kappaB Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Telomere Maintenance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cell Redox Homeostasis Regulation Of Telomere Maintenance Via Telomerase
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?