CEBPB and KAT2A

Number of citations of the paper that reports this interaction (PubMedID 30884312)
75

Data Source:
BioGRID (pull down, enzymatic study, pull down, affinity chromatography technology)

		CEBPB	KAT2A
Description		CCAAT enhancer binding protein beta	lysine acetyltransferase 2A
Image
GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix CHOP-C/EBP Complex RNA Polymerase II Transcription Regulator Complex C/EBP Complex	Histone Acetyltransferase Complex SAGA Complex Chromatin Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle ATAC Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Chromatin DNA Binding Histone Acetyltransferase Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Phosphatase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone Glutaryltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Liver Development Embryonic Placenta Development Granuloma Formation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Acute-phase Response Inflammatory Response Immune Response Memory Positive Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-4 Production Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress T-helper 1 Cell Activation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Fat Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Myeloid Cell Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Interleukin-1 Hepatocyte Proliferation Liver Regeneration Positive Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling Regulation Of Odontoblast Differentiation Positive Regulation Of Sodium-dependent Phosphate Transport Regulation Of Dendritic Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Neural Tube Closure Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Heart Development Long-term Memory Regulation Of Gene Expression Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Multicellular Organism Growth Protein Modification Process Regulation Of RNA Splicing Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Fibroblast Proliferation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Regulation Of Cell Division Regulation Of Cell Cycle Limb Development Regulation Of Cartilage Development Regulation Of Small Molecule Metabolic Process Cellular Response To Tumor Necrosis Factor Peptidyl-lysine Glutarylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) ATF4 activates genes in response to endoplasmic reticulum stress Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional Regulation by VENTX Transcriptional regulation of granulopoiesis Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Nuclear events stimulated by ALK signaling in cancer	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm
Drugs		Quercetin	Coenzyme A
Diseases
GWAS		Bronchodilator response in asthma ( 25562107) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Meconium ileus in cystic fibrosis ( 30807572) Pancreas fat ( 34128465) Type 2 diabetes ( 30297969 30718926 32499647)	Coronary artery disease ( 29212778 33020668) Inflammatory bowel disease ( 26278503) Mean reticulocyte volume ( 32888494) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		58 interacting genes: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 DMAP1 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED20 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 NUP50 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIB1 TRIM28	67 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPA CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL ECHS1 EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-4 H3C1 H3C14 H4C14 H4C16 H4C7 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PRKDC PYGO2 RASSF1 RBPJ RELA RPA1 SIRT2 SNCA STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6
Entrez ID		1051	2648
HPRD ID		01801	03807
Ensembl ID		ENSG00000172216	ENSG00000108773
Uniprot IDs		P17676	Q92830
PDB IDs		1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43 6MG1 6MG2 6MG3 7L4V 7UPZ 8K8D	1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P 8E6O 8H65 8H66 8H6C 8H6D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Binding DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Regulation Of MiRNA Transcription Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of Developmental Process DNA-templated Transcription Positive Regulation Of Multicellular Organismal Process	Nucleus Nucleoplasm Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Nucleosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Protein Heterodimerization Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Hemopoiesis DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Mitotic Cell Cycle Phase Transition Mononuclear Cell Differentiation Nucleosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cell Cycle Phase Transition Chromosome
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