CEBPB and FOXO1

Number of citations of the paper that reports this interaction (PubMedID 11893744)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		CEBPB	FOXO1
Description		CCAAT enhancer binding protein beta	forkhead box O1
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GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix CHOP-C/EBP Complex RNA Polymerase II Transcription Regulator Complex C/EBP Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Chromatin DNA Binding Histone Acetyltransferase Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Liver Development Embryonic Placenta Development Granuloma Formation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Acute-phase Response Inflammatory Response Immune Response Memory Positive Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-4 Production Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress T-helper 1 Cell Activation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Fat Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Myeloid Cell Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Interleukin-1 Hepatocyte Proliferation Liver Regeneration Positive Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling Regulation Of Odontoblast Differentiation Positive Regulation Of Sodium-dependent Phosphate Transport Regulation Of Dendritic Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Temperature Homeostasis Intracellular Glucose Homeostasis Gluconeogenesis Regulation Of Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Autophagy Apoptotic Process DNA Damage Response Insulin Receptor Signaling Pathway Cellular Response To Starvation Gene Expression Positive Regulation Of Autophagy Cell Differentiation Response To Insulin Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Cell Population Proliferation Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Canonical Wnt Signaling Pathway Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Cold Response To Fatty Acid Cellular Response To Hyperoxia Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Energy Homeostasis Neuronal Stem Cell Population Maintenance Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) ATF4 activates genes in response to endoplasmic reticulum stress Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional Regulation by VENTX Transcriptional regulation of granulopoiesis Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Nuclear events stimulated by ALK signaling in cancer	AKT phosphorylates targets in the nucleus Regulation of gene expression in beta cells AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
Drugs		Quercetin
Diseases			Alveolar rhabdomyosarcoma
GWAS		Bronchodilator response in asthma ( 25562107) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Meconium ileus in cystic fibrosis ( 30807572) Pancreas fat ( 34128465) Type 2 diabetes ( 30297969 30718926 32499647)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Central corneal thickness ( 32528159 29760442 20485516 31798171 20719862) Corneal hysteresis ( 32716492 31246245 30894546) Corneal resistance factor ( 32716492 31246245 30894546) Corneal structure ( 23291589) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) Intraocular pressure ( 29617998 29235454) Mean corpuscular hemoglobin ( 32888494 29403010 27863252) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 31649266 30194396) Weight ( 28552196)
Interacting Genes		58 interacting genes: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 DMAP1 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED20 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 NUP50 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIB1 TRIM28	39 interacting genes: AKT1 AR CDK1 CEBPB CREBBP CSNK1G1 CTNNB1 DACH1 DANCR DYRK1A ESR1 FHL2 FOXG1 G6PC1 GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 NCOA1 NEDD4L PAK1 PARP1 PIK3R3 PITX1 PPARG RARA SET SFN SIRT1 SMAD3 SMAD4 SRC THRB TNS2 YWHAG YWHAZ
Entrez ID		1051	2308
HPRD ID		01801	00645
Ensembl ID		ENSG00000172216	ENSG00000150907
Uniprot IDs		P17676	Q12778
PDB IDs		1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43 6MG1 6MG2 6MG3 7L4V 7UPZ 8K8D	3CO6 3CO7 3COA 4LG0 5DUI 6LBI 6QVW 6QZR 6QZS 8A62 8A65
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Binding DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Regulation Of MiRNA Transcription Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of Developmental Process DNA-templated Transcription Positive Regulation Of Multicellular Organismal Process	Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Differentiation Animal Organ Development Regulation Of Protein Localization Chromatin Transcription Regulator Complex Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Developmental Process Transcription Coactivator Binding Negative Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation
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