CEBPB and PTGES2

Number of citations of the paper that reports this interaction (PMID 15879117)
5

Data Source:
HPRD (in vivo, in vitro)

		CEBPB	PTGES2
Gene Name		CCAAT/enhancer binding protein (C/EBP), beta	prostaglandin E synthase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix	Golgi Membrane Nucleus Mitochondrion Cytosol Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	DNA Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Lyase Activity Heme Binding Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Inflammatory Response Immune Response Neuron Differentiation Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Negative Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Regulation Of Transcription Involved In Cell Fate Commitment Cellular Response To Amino Acid Stimulus	Prostaglandin Biosynthetic Process Cell Redox Homeostasis Positive Regulation Of Transcription, DNA-templated Secretion Oxidation-reduction Process
Pathways		Transcriptional regulation of white adipocyte differentiation Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		54 interactors: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIM28	4 interactors: C1orf189 CEBPB EXOSC10 PTGFR
Entrez ID		1051	80142
HPRD ID		01801	07458
Ensembl ID		ENSG00000172216	ENSG00000148334
Uniprot IDs		P17676	A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7
PDB IDs		1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression DNA-templated Transcription, Initiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune System Process Cellular Metabolic Process System Development Developmental Process Gland Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus	Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Cellular Response To Acid Chemical Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Cellular Response To Prostaglandin D Stimulus Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Response To Bacterium Intracellular MRNA Localization Dosage Compensation RRNA Catabolic Process Calcium-mediated Signaling Using Intracellular Calcium Source Maturation Of 5.8S RRNA Parturition Cellular Response To Prostaglandin Stimulus Histone MRNA Metabolic Process Response To Other Organism Regulation Of Interleukin-6 Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Mammary Gland Epithelial Cell Differentiation Regulation Of Transcription Involved In Cell Fate Commitment Response To Biotic Stimulus Response To Lipid RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Acute-phase Response Negative Regulation Of Cell Death Brown Fat Cell Differentiation Cellular Response To Fatty Acid Positive Regulation Of Fat Cell Differentiation Cellular Response To Amino Acid Stimulus Reproductive Process Response To Fatty Acid Positive Regulation Of Osteoblast Differentiation Acute Inflammatory Response Regulation Of Apoptotic Process Epithelial Cell Proliferation Calcium-mediated Signaling Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cell Death Positive Regulation Of Ossification Mammary Gland Epithelium Development Regulation Of Interleukin-6 Production RNA Phosphodiester Bond Hydrolysis Regulation Of Cytokine Biosynthetic Process
Tagcloud ?		activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?		activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?