RFWD3 and ORC2

Number of citations of the paper that reports this interaction (PubMedID 33044890)
48

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RFWD3	ORC2
Description		ring finger and WD repeat domain 3	origin recognition complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage	Chromosome, Telomeric Region Chromatin Heterochromatin Origin Recognition Complex Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation
Pathways			E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 23666239 28604728 28604732)	Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		17 interacting genes: APP CFTR ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	29 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4C16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RFWD3 RIPPLY3 RPA1 RPA2 XRCC5
Entrez ID		55159	4999
HPRD ID		07678	03112
Ensembl ID		ENSG00000168411	ENSG00000115942
Uniprot IDs		Q6PCD5	Q13416
PDB IDs		6CVZ	5C8H 5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Monoubiquitination Protein Modification By Small Protein Conjugation ATP Binding DNA Metabolic Process Macromolecule Metabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Nucleus Protein K11-linked Ubiquitination Nucleotide Binding Proteolysis Involved In Protein Catabolic Process DNA Replication DNA Repair Nucleoplasm Ubiquitin-dependent Protein Catabolic Process Chromosome, Telomeric Region Telomere Maintenance Macromolecule Catabolic Process Mismatch Repair DNA Damage Response Telomere Organization Proteolysis Protein Modification Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Origin Recognition Complex Male Germ Cell Nucleus Nuclear Origin Of Replication Recognition Complex TORC1 Signaling Damaged DNA Binding Negative Regulation Of TORC1 Signaling Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Cellular Response To Stress Protein-containing Complex Double-strand Break Repair DNA Replication Factor A Complex DNA Recombination TOR Signaling Chromatin Binding Lateral Element Negative Regulation Of TOR Signaling DNA Replication Origin Binding Transferase Activity Site Of Double-strand Break	DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication Nucleic Acid Metabolic Process CMG Complex Double-strand Break Repair Via Break-induced Replication Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Recombinational Repair Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Repair Chromosome MCM Complex Double-strand Break Repair Via Homologous Recombination Nucleoplasm Origin Recognition Complex Double-strand Break Repair DNA Recombination DNA Binding Single-stranded DNA Helicase Activity Cellular Response To Stress Nucleus Macromolecule Metabolic Process Helicase Activity Negative Regulation Of Cell Cycle Phase Transition DNA Helicase Activity ATP Hydrolysis Activity Mitotic DNA Replication Initiation Negative Regulation Of Cell Cycle Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Damaged DNA Binding Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling ATP Binding Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Site Of DNA Damage Regulation Of Cell Cycle Protein Localization To Chromosome DNA Replication Factor A Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Mitotic G1 DNA Damage Checkpoint Signaling
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