RFWD3 and RPA3

Number of citations of the paper that reports this interaction (PubMedID 29576527)
60

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		RFWD3	RPA3
Description		ring finger and WD repeat domain 3	replication protein A3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage	Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation
Pathways			Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 23666239 28604728 28604732)	Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Estimated glomerular filtration rate ( 29779033) Insulin-like growth factors ( 21216879) Interstitial lung diseases in rheumatoid arthritis ( 32737115) Intraocular pressure ( 30591961) Serum creatinine levels ( 29779033) Urate levels in obese individuals ( 25811787)
Interacting Genes		17 interacting genes: APP CFTR ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	10 interacting genes: ATRIP ERCC1 MCM2 PRPF19 RAD51 RFWD3 RPA1 RPA2 RPA4 WAS
Entrez ID		55159	6119
HPRD ID		07678	01567
Ensembl ID		ENSG00000168411	ENSG00000106399
Uniprot IDs		Q6PCD5	A4D105 P35244
PDB IDs		6CVZ	1L1O 1QUQ 2PI2 2PQA 2Z6K 3KDF 8RK2 9MJ5
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Monoubiquitination Protein Modification By Small Protein Conjugation ATP Binding DNA Metabolic Process Macromolecule Metabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Nucleus Protein K11-linked Ubiquitination Nucleotide Binding Proteolysis Involved In Protein Catabolic Process DNA Replication DNA Repair Nucleoplasm Ubiquitin-dependent Protein Catabolic Process Chromosome, Telomeric Region Telomere Maintenance Macromolecule Catabolic Process Mismatch Repair DNA Damage Response Telomere Organization Proteolysis Protein Modification Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Origin Recognition Complex Male Germ Cell Nucleus Nuclear Origin Of Replication Recognition Complex TORC1 Signaling Damaged DNA Binding Negative Regulation Of TORC1 Signaling Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Cellular Response To Stress Protein-containing Complex Double-strand Break Repair DNA Replication Factor A Complex DNA Recombination TOR Signaling Chromatin Binding Lateral Element Negative Regulation Of TOR Signaling DNA Replication Origin Binding Transferase Activity Site Of Double-strand Break	Site Of Double-strand Break Double-strand Break Repair DNA Repair DNA Metabolic Process Single-stranded DNA Binding DNA Recombination DNA Damage Response DNA Replication Factor A Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Cellular Response To Stress Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Telomere Maintenance Regulation Of DNA Damage Checkpoint Response To Stress PML Body Nuclear Chromosome Regulation Of Cell Cycle Telomere Organization Nucleobase-containing Compound Metabolic Process DNA Replication Regulation Of Double-strand Break Repair Interstrand Cross-link Repair Damaged DNA Binding Regulation Of DNA Repair G-rich Strand Telomeric DNA Binding Nucleus Regulation Of Double-strand Break Repair Via Homologous Recombination Intracellular Signal Transduction Telomere Maintenance Via Recombination Lateral Element Mitotic G1 DNA Damage Checkpoint Signaling Chromosome Organization Mitotic G1/S Transition Checkpoint Signaling Single-stranded DNA Helicase Activity Nucleoplasm Mitotic Recombination Regulation Of DNA Recombination Response To Ionizing Radiation
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