RFWD3

Gene Name		ring finger and WD repeat domain 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body Site Of Double-strand Break
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	DNA Repair Response To Ionizing Radiation Protein Ubiquitination Mitotic G1 DNA Damage Checkpoint Regulation Of DNA Damage Checkpoint
Pathways
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-protein Interactions		10 interactors: APP RPA2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		55159
HPRD ID		07678
Ensembl ID		ENSG00000168411
Uniprot IDs		Q6PCD5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Modification Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein K63-linked Ubiquitination Protein Monoubiquitination Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Cell Cycle Phase Transition Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Stress Cellular Response To Oxygen Levels Proteolysis Protein Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Immune Response-regulating Signaling Pathway Regulation Of Cell Cycle Process Mitotic Cell Cycle Checkpoint Response To Abiotic Stimulus
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