RFWD3

Description		ring finger and WD repeat domain 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint
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Drugs
Diseases
GWAS		Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 23666239 28604728 28604732)
Interacting Genes		17 interacting genes: APP CFTR ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		55159
HPRD ID		07678
Ensembl ID		ENSG00000168411
Uniprot IDs		Q6PCD5
PDB IDs		6CVZ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Monoubiquitination Protein Modification By Small Protein Conjugation ATP Binding DNA Metabolic Process Macromolecule Metabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Nucleus Protein K11-linked Ubiquitination Nucleotide Binding Proteolysis Involved In Protein Catabolic Process DNA Replication DNA Repair Nucleoplasm Ubiquitin-dependent Protein Catabolic Process Chromosome, Telomeric Region Telomere Maintenance Macromolecule Catabolic Process Mismatch Repair DNA Damage Response Telomere Organization Proteolysis Protein Modification Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Origin Recognition Complex Male Germ Cell Nucleus Nuclear Origin Of Replication Recognition Complex TORC1 Signaling Damaged DNA Binding Negative Regulation Of TORC1 Signaling Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Cellular Response To Stress Protein-containing Complex Double-strand Break Repair DNA Replication Factor A Complex DNA Recombination TOR Signaling Chromatin Binding Lateral Element Negative Regulation Of TOR Signaling DNA Replication Origin Binding Transferase Activity Site Of Double-strand Break
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