BAIAP2 and SHANK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		BAIAP2	SHANK2
Description		BAR/IMD domain containing adaptor protein 2	SH3 and multiple ankyrin repeat domains 2
Image
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Secretory Granule Filopodium Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Neuron Projection Terminus Excitatory Synapse Neuron Projection Branch Point Dendritic Spine Cytoplasm Extracellular Exosome Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Presynaptic Cytosol Postsynaptic Cytosol	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Transcription Coregulator Binding Protein Binding Cytoskeletal Anchor Activity PDZ Domain Binding Identical Protein Binding Proline-rich Region Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Dendrite Development Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Protein Localization To Synapse Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Actin Filament Bundle Assembly Actin Crosslink Formation Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cell-cell Adhesion Regulation Of Postsynapse Organization Cellular Response To L-glutamate Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Excitatory Postsynaptic Potential	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		42 interacting genes: ADGRB1 APP ATN1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 NRIP1 OGT PAK1 PBX2 PKNOX1 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SHANK3 SRPK2 TBX5 TP53BP2 UBC WASF2 YWHAG	21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		10458	22941
HPRD ID		05686	04479
Ensembl ID		ENSG00000175866	ENSG00000162105
Uniprot IDs		I3L4C2 Q9UQB8	A0A590UJ45 A6NHU9 Q9UPX8
PDB IDs		1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI	8ATJ 8B10
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synapse Assembly SH3 Domain Binding Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Synapse Cell Projection Synaptic Receptor Adaptor Activity MPP7-DLG1-LIN7 Complex Ruffle Membrane Positive Regulation Of Cell Projection Organization Regulation Of Developmental Process Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Cell Projection Morphogenesis Regulation Of Cytoskeleton Organization Cell-cell Junction Glutamatergic Synapse Cell Motility Regulation Of Neuron Projection Development Ionotropic Glutamate Receptor Binding Cell Migration Regulation Of Postsynapse Organization Postsynaptic Membrane Regulation Of Actin Cytoskeleton Organization Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Cellular Component Organization Neuron Projection Development Intracellular Signal Transduction Postsynaptic Density Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Organization Postsynapse Organization Anatomical Structure Morphogenesis Anchoring Junction Plasma Membrane Negative Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Developmental Growth Dendritic Spine Morphogenesis Positive Regulation Of Cell Communication Regulation Of Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Protein Localization To Lysosome	Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?