BAIAP2 and HOXD8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BAIAP2	HOXD8
Description		BAR/IMD domain containing adaptor protein 2	homeobox D8
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Secretory Granule Filopodium Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Neuron Projection Terminus Excitatory Synapse Neuron Projection Branch Point Dendritic Spine Cytoplasm Extracellular Exosome Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Presynaptic Cytosol Postsynaptic Cytosol	Chromatin Nucleus
	Molecular Function	Transcription Coregulator Binding Protein Binding Cytoskeletal Anchor Activity PDZ Domain Binding Identical Protein Binding Proline-rich Region Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Dendrite Development Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Protein Localization To Synapse Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Actin Filament Bundle Assembly Actin Crosslink Formation Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cell-cell Adhesion Regulation Of Postsynapse Organization Cellular Response To L-glutamate Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Excitatory Postsynaptic Potential	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Axis Specification, Embryo Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Glomerular filtration rate (creatinine) ( 28452372) Male-pattern baldness ( 28196072) Urate levels ( 31578528)
Interacting Genes		42 interacting genes: ADGRB1 APP ATN1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 NRIP1 OGT PAK1 PBX2 PKNOX1 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SHANK3 SRPK2 TBX5 TP53BP2 UBC WASF2 YWHAG	8 interacting genes: ANXA7 BAIAP2 CDKN1A HMGB1 LDLRAP1 NCK2 PFDN1 RCC1
Entrez ID		10458	3234
HPRD ID		05686	00868
Ensembl ID		ENSG00000175866	ENSG00000175879
Uniprot IDs		I3L4C2 Q9UQB8	A0A0A0MSX5 P13378
PDB IDs		1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synapse Assembly SH3 Domain Binding Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Synapse Cell Projection Synaptic Receptor Adaptor Activity MPP7-DLG1-LIN7 Complex Ruffle Membrane Positive Regulation Of Cell Projection Organization Regulation Of Developmental Process Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Cell Projection Morphogenesis Regulation Of Cytoskeleton Organization Cell-cell Junction Glutamatergic Synapse Cell Motility Regulation Of Neuron Projection Development Ionotropic Glutamate Receptor Binding Cell Migration Regulation Of Postsynapse Organization Postsynaptic Membrane Regulation Of Actin Cytoskeleton Organization Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Cellular Component Organization Neuron Projection Development Intracellular Signal Transduction Postsynaptic Density Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Organization Postsynapse Organization Anatomical Structure Morphogenesis Anchoring Junction Plasma Membrane Negative Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Developmental Growth Dendritic Spine Morphogenesis Positive Regulation Of Cell Communication Regulation Of Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Protein Localization To Lysosome	Regulation Of Cellular Component Organization Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cytoskeletal Anchor Activity Positive Regulation Of Leukocyte Proliferation Signaling Receptor Complex Adaptor Activity Vesicle Membrane Cytoplasm Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Phosphatidylserine Binding Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Population Proliferation PCNA-p21 Complex Cell Cycle G1/S Phase Transition Negative Regulation Of Cardiac Muscle Tissue Regeneration G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Activation Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Regulation Of Supramolecular Fiber Organization Amyloid-beta Binding Positive Regulation Of Protein Polymerization Signaling Adaptor Activity Scaffold Protein Binding Dendritic Spine Cytoplasm Neuron Projection Branch Point Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Protein-containing Complex Assembly Positive Regulation Of T Cell Proliferation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Positive Regulation Of Intracellular Cholesterol Transport Regulation Of Lymphocyte Activation Cellular Response To Cell-matrix Adhesion Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress
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