BAIAP2 and PRR13

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		BAIAP2	PRR13
Description		BAR/IMD domain containing adaptor protein 2	proline rich 13
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Secretory Granule Filopodium Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Neuron Projection Terminus Excitatory Synapse Neuron Projection Branch Point Dendritic Spine Cytoplasm Extracellular Exosome Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Presynaptic Cytosol Postsynaptic Cytosol	Nucleus Nucleoplasm Cytosol
	Molecular Function	Transcription Coregulator Binding Protein Binding Cytoskeletal Anchor Activity PDZ Domain Binding Identical Protein Binding Proline-rich Region Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Protein Binding
	Biological Process	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Dendrite Development Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Protein Localization To Synapse Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Actin Filament Bundle Assembly Actin Crosslink Formation Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cell-cell Adhesion Regulation Of Postsynapse Organization Cellular Response To L-glutamate Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252)
Interacting Genes		42 interacting genes: ADGRB1 APP ATN1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 NRIP1 OGT PAK1 PBX2 PKNOX1 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SHANK3 SRPK2 TBX5 TP53BP2 UBC WASF2 YWHAG	53 interacting genes: AP2M1 BAIAP2 CBLL2 CELF5 DAZAP2 DVL3 EWSR1 FAM133A FUBP1 FXR1 GPAA1 H2BC15 IL16 KHDC4 KLHL12 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP13-1 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP4-12 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LGALS3 LNX1 MSX2 NKX1-2 OTX1 PEX5 PLSCR1 PPIA PSMA3 PSME3 RBM47 RP9P RTN4 SDCBP SDCBP2 SMUG1 SREK1IP1 SRI TIAL1 TNFAIP8 TRIP13 VAC14 YPEL3 ZCCHC10
Entrez ID		10458	54458
HPRD ID		05686	13211
Ensembl ID		ENSG00000175866	ENSG00000205352
Uniprot IDs		I3L4C2 Q9UQB8	Q9NZ81
PDB IDs		1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synapse Assembly SH3 Domain Binding Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Synapse Cell Projection Synaptic Receptor Adaptor Activity MPP7-DLG1-LIN7 Complex Ruffle Membrane Positive Regulation Of Cell Projection Organization Regulation Of Developmental Process Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Cell Projection Morphogenesis Regulation Of Cytoskeleton Organization Cell-cell Junction Glutamatergic Synapse Cell Motility Regulation Of Neuron Projection Development Ionotropic Glutamate Receptor Binding Cell Migration Regulation Of Postsynapse Organization Postsynaptic Membrane Regulation Of Actin Cytoskeleton Organization Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Cellular Component Organization Neuron Projection Development Intracellular Signal Transduction Postsynaptic Density Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Organization Postsynapse Organization Anatomical Structure Morphogenesis Anchoring Junction Plasma Membrane Negative Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Developmental Growth Dendritic Spine Morphogenesis Positive Regulation Of Cell Communication Regulation Of Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Protein Localization To Lysosome	Intermediate Filament Cytosol Keratin Filament Identical Protein Binding
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