BAIAP2 and ESPN

Number of citations of the paper that reports this interaction (PubMedID 12598619)
70

Data Source:
HPRD (two hybrid, in vitro)

		BAIAP2	ESPN
Description		BAR/IMD domain containing adaptor protein 2	espin
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Secretory Granule Filopodium Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Neuron Projection Terminus Excitatory Synapse Neuron Projection Branch Point Dendritic Spine Cytoplasm Extracellular Exosome Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Presynaptic Cytosol Postsynaptic Cytosol	Cytoplasm Cytoskeleton Microvillus Brush Border Filamentous Actin Stereocilium Stereocilium Tip Cell Projection Organelle Actin-based Cell Projection Cluster Of Actin-based Cell Projections
	Molecular Function	Transcription Coregulator Binding Protein Binding Cytoskeletal Anchor Activity PDZ Domain Binding Identical Protein Binding Proline-rich Region Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Actin Binding SH3 Domain Binding Actin Filament Binding
	Biological Process	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Dendrite Development Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Protein Localization To Synapse Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Actin Filament Bundle Assembly Actin Crosslink Formation Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cell-cell Adhesion Regulation Of Postsynapse Organization Cellular Response To L-glutamate Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Excitatory Postsynaptic Potential	Sensory Perception Of Sound Microvillar Actin Bundle Assembly Actin Filament Bundle Assembly
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases			Deafness, autosomal recessive
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Carotid intima media thickness x smoking interaction ( 32117412) Male-pattern baldness ( 29146897) Multiple sclerosis ( 31604244)
Interacting Genes		42 interacting genes: ADGRB1 APP ATN1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 NRIP1 OGT PAK1 PBX2 PKNOX1 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SHANK3 SRPK2 TBX5 TP53BP2 UBC WASF2 YWHAG	1 interacting genes: BAIAP2
Entrez ID		10458	83715
HPRD ID		05686	06962
Ensembl ID		ENSG00000175866	ENSG00000187017
Uniprot IDs		I3L4C2 Q9UQB8	B1AK53
PDB IDs		1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synapse Assembly SH3 Domain Binding Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Synapse Cell Projection Synaptic Receptor Adaptor Activity MPP7-DLG1-LIN7 Complex Ruffle Membrane Positive Regulation Of Cell Projection Organization Regulation Of Developmental Process Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Cell Projection Morphogenesis Regulation Of Cytoskeleton Organization Cell-cell Junction Glutamatergic Synapse Cell Motility Regulation Of Neuron Projection Development Ionotropic Glutamate Receptor Binding Cell Migration Regulation Of Postsynapse Organization Postsynaptic Membrane Regulation Of Actin Cytoskeleton Organization Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Cellular Component Organization Neuron Projection Development Intracellular Signal Transduction Postsynaptic Density Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Organization Postsynapse Organization Anatomical Structure Morphogenesis Anchoring Junction Plasma Membrane Negative Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Developmental Growth Dendritic Spine Morphogenesis Positive Regulation Of Cell Communication Regulation Of Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Protein Localization To Lysosome	Dendritic Spine Cytoplasm Neuron Projection Branch Point Neuron Projection Terminus Regulation Of Modification Of Postsynaptic Structure Response To L-glutamate Proline-rich Region Binding Cadherin Binding Involved In Cell-cell Adhesion Actin Crosslink Formation Postsynaptic Density, Intracellular Component Cellular Response To L-glutamate Regulation Of Modification Of Synaptic Structure Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cytoskeletal Anchor Activity Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Dendritic Spine Development Dendritic Shaft Transcription Coregulator Binding Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Dendritic Spine Morphogenesis Excitatory Synapse Cellular Response To Epidermal Growth Factor Stimulus Dendrite Development Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Actin Filament Polymerization Response To Epidermal Growth Factor Regulation Of Dendritic Spine Development Regulation Of Dendrite Morphogenesis Protein Localization To Synapse Actin Filament Bundle Organization Synaptic Membrane Actin Filament Bundle Assembly Scaffold Protein Binding Positive Regulation Of Protein Polymerization Filopodium Protein Localization To Cell Junction Insulin Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus PDZ Domain Binding Regulation Of Dendrite Development Schaffer Collateral - CA1 Synapse Secretory Granule Ruffle Response To Amino Acid Regulation Of Actin Filament Polymerization Plasma Membrane Organization Regulation Of Nervous System Process Regulation Of Actin Polymerization Or Depolymerization
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