OLFM1 and RUNX1

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		OLFM1	RUNX1
Name		olfactomedin 1	RUNX family transcription factor 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Axon Cell Projection Neuronal Cell Body Perikaryon Axonal Growth Cone Synapse	Chromatin Nucleus Nucleoplasm Core-binding Factor Complex
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Atrioventricular Valve Formation Signal Transduction Nervous System Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Neuronal Signal Transduction Regulation Of Axon Extension Positive Regulation Of Apoptotic Process Cardiac Epithelial To Mesenchymal Transition Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Myeloid Leukocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Plasminogen Activation Hemopoiesis Myeloid Cell Differentiation Neuron Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Tissue Regeneration Hematopoietic Stem Cell Proliferation Positive Regulation Of Extracellular Matrix Organization Regulation Of Connective Tissue Replacement Regulation Of Multicellular Organismal Development
Pathways		None	Pre-NOTCH Transcription and Translation SLC-mediated transport of organic cations RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis SARS-CoV-1 activates/modulates innate immune responses Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Diseases		None	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Acute myeloid leukemia (AML) Chronic myeloid leukemia (CML) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Blood protein levels ( 30072576 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Interleukin-10 levels ( 22205395 ) Obesity-related traits ( 23251661 ) Response to hepatitis C treatment ( 22095909 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Trans-epidermal water loss ( 28011148 )	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Appendicular lean mass ( 33097823 ) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 ) Asthma (adult onset) ( 31036433 30929738 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Brain-derived neurotrophic factor levels ( 33345186 ) Breast cancer ( 31757997 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Core binding factor acute myeloid leukemia ( 27903959 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Esophageal cancer ( 21642993 ) Esophageal squamous cell carcinoma ( 25129146 ) Femoral neck length ( 30888730 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gut microbiota alpha diversity (Chao1 index) ( 33208821 ) HDL cholesterol ( 30275531 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Hip index ( 34021172 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Male-pattern baldness ( 28196072 29146897 27182965 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Myeloproliferative neoplasms ( 33057200 ) Neutrophil percentage of granulocytes ( 27863252 ) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 32888494 27863252 ) Preeclampsia ( 23551011 ) Psoriasis ( 25903422 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30423114 23143596 24390342 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Stroke ( 32693751 ) Sum eosinophil basophil counts ( 27863252 ) White blood cell count (basophil) ( 27863252 )
Interacting Genes		6 interacting genes: APP DISC1 EGFR MEOX2 RUNX1 TRAF3IP1	119 interacting genes: ABCA2 ABHD14A AGTPBP1 ALKBH6 APEH AR ARGLU1 ARID5B ATP13A1 B4GAT1 BAG3 BAG4 BTBD2 CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CCNK CDK1 CDK2 CDK6 CEBPA CEBPB CERCAM CLIP4 CNOT3 CNRIP1 COPA COPRS DAZAP2 DNMT1 DTX2 DZIP3 EEF2 ELF1 ELF2 ELF4 EP300 FAM222B FBXO17 FOS FOXP3 FOXRED1 GCC1 GDI1 GSK3A GTPBP6 HGS HIPK1 HIPK2 HLA-DRB1 IDS IKZF1 IKZF3 JUN KAT6A KAT6B MAGI3 MAPK1 ME3 METTL26 MPPED2 MSTO1 MYOD1 NCOR1 NCOR2 NDST1 NFKBID OLFM1 OLIG3 PAX5 PICK1 PKD1 PLEKHB1 PLEKHB2 PPP3CB PRDM4 PRMT1 PRRC2A PSMB4 RBFOX3 RBM14 RNF38 RNF44 SEC31B SNRNP70 SNRPC SPEN SPI1 STUB1 SULT4A1 SUV39H1 TAFAZZIN TCERG1 TEAD2 TEAD4 TEKT5 TLE1 TLE2 TLE5 TMEM222 TOLLIP TRIM5 TUBA1B UBE2L6 UHRF2 UROD USP10 UXT VDR VPS37C VPS39 WBP2 WWP1 WWTR1 YAP1 ZMYM4
Entrez ID		10439	861
HPRD ID		09249	01043
Ensembl ID		ENSG00000130558	ENSG00000159216
Uniprot IDs		Q6IMJ7 Q6IMJ8 Q99784	Q01196
PDB IDs		4XAT 6QHJ	1CMO 1CO1 1E50 1H9D 1LJM
GO Terms Enriched among Interactors		Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Growth Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of MiRNA Transcription Amylin Binding Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Telencephalon Cell Migration Cerebral Cortex Cell Migration Forebrain Cell Migration Ciliary Basal Body Multivesicular Body, Internal Vesicle Lumen Ciliary Base Cell Body Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization PTB Domain Binding Regulation Of Phosphorus Metabolic Process Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Transcription By RNA Polymerase II Ossification Core-binding Factor Complex Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Mitochondrial Processing Peptidase Complex Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling	Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Coactivator Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cellular Developmental Process Regulation Of Cell Differentiation Chromatin Binding Developmental Process Leukocyte Differentiation Mononuclear Cell Differentiation Chromatin Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Chromatin Remodeling Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription By RNA Polymerase II